嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Human and animal eosinophils contain a powerful neurotoxin that causes selective neuronal and axonal damage to white matter of cerebellum and spinal cord of experimental animals when injected intrathecally. This reaction is termed the "Gordon phenomenon." We purified the eosinophil-derived neurotoxin from eosinophil-rich leukocyte suspensions or eosinophil granules from four patients with various hypereosinophilic syndromes. A single protein with an average molecular weight of 18,400 was isolated by sequential chromatography on Sephadex G-50 columns and analyzed by sodium dodecyl嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体 sulfate/polyacrylamide gel electrophoresis of column fractions. The purified eosinophil-derived neurotoxin from the cells of these patients retained the potent neurotoxic activity of the crude eosinophil or eosinophil granule extracts in experimental animals. These animals developed the syndrome of stiffness and ataxia progressing to severe paralysis characteristic of the Gordon phenomenon. Histologic examination of the brains of animals injected with purified eosinophil-derived neurotoxin confirmed the characteristic widespread loss of Purkinje cells and severe spongiform vacuolation in the white matter of cerebellum, brain stem, and spinal cord. We have established 嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体the location of eosinophil-derived neurotoxin in the eosinophil granule and have shown that it is distinct from several other eosinophil proteins, the granule major basic protein, and the Charcot-Leyden crystal protein (lysophospholipase).

Also known as:

RNASE2; EDN; RNS2; RNAS2_HUMAN; Non-secretory ribonuclease; Eosinophil-derived neurotoxin;; RNase UpI-2; Ribonuclease 2; RNase 2; Ribonuclease US; Ear4; EC=3.1.27.5; EDN; Eosinophil cationic type ribonuclease 4; MR 4; Non secretory ribonuclease; R14; R15; R5;嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体 Ribonuclease 2; Ribonuclease RNase A family 2 (liver eosinophil derived neurotoxin); Ribonuclease US; RNase 2; RNase UpI 2.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from human RNASE2.

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Predicted Molecular Weight: 14kDa.

嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

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