磷酸化非受体酪氨酸激酶c-Abl抗体

Quantity size:

0.1ml

Concentration:

1mg/ml磷酸化非受体酪氨酸激酶c-Abl抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in 磷酸化非受体酪氨酸激酶c-Abl抗体the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

磷酸化非受体酪氨酸激酶c-Abl抗体Also known as:

c Abl(phospho S569); p-c Abl(phospho S569); p-c Abl(phospho Ser569); Abelson Murine Leukemia Viral Oncogene Homolog 1; Abelson murine leukemia viral v abl oncogene homolog 1; Abl 1; ABL; Abl protein; Abl1; Bcr/c abl oncogene protein; JTK 7; JTK7; p150 ; Proto oncogene tyrosine protein kinase ABL1; Transformation gene oncogene ABL; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; ABL1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,磷酸化非受体酪氨酸激酶c-Abl抗体 affinity purified by Protein A.

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Reacts with: Human, Pig, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Ser569.

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Predicted Molecular Weight: 123kDa.

磷酸化非受体酪氨酸激酶c-Abl抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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