肿瘤抑制基因UVRAG抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 肿瘤抑制基因UVRAG抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon 肿瘤抑制基因UVRAG抗体cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.

肿瘤抑制基因UVRAG抗体Also known as:

DHTX; Disrupted in heterotaxy; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated gene protein; UV radiation resistance-associated gene protein; UVRAG; UVRAG_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,肿瘤抑制基因UVRAG抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from Human UVRAG/DHTX.

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Predicted Molecular Weight: 78kDa.

Storage:

肿瘤抑制基因UVRAG抗体Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:50-200   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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