磷酸化鸟嘌呤核苷酸交换因子VAV3抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化鸟嘌呤核苷酸交换因子VAV3抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and 磷酸化鸟嘌呤核苷酸交换因子VAV3抗体subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.

磷酸化鸟嘌呤核苷酸交换因子VAV3抗体Also known as:

VAV3(phospho Y141); Guanine nucleotide exchange factor VAV3; Protein vav 3; Protein vav3; VAV 3; Vav 3 guanine nucleotide exchange factor; VAV 3 oncogene; VAV 3 protein; VAV-3; Vav3; VAV3 oncogene; VAV3 protein; VAV3_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, 磷酸化鸟嘌呤核苷酸交换因子VAV3抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human VAV3 around the phosphorylation site of Tyr141.

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Predicted Molecular Weight: 93kDa.

Storage:

磷酸化鸟嘌呤核苷酸交换因子VAV3抗体Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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