超分辨离体光遗传系统

系统简介
超分辨离体光遗传系统使用声光偏转器控制激光扫描，能够快速、选择性的光刺激激活光敏感通道表达的细胞、神经元或脑片，并能与电生理记录系统、荧光成像系统等同步工作，将可用于研究神经元计算整合过程、确定神经元投射关系以及研究神经环路机制。
随机扫描光刺激系统采用优化的光学设计和模块化的机械设计，扫描箱体积300mmx220mmx180mm，重量2.5kg。基于Labview开发的应用软件，操作方便，可读性好，便于升级。系统具有刺激时间、刺激间隔、刺激位置、刺激强度、刺激方式等多参数精准调控。系统结构紧凑、刺激精度高、刺激稳定，易与多种型号显微镜耦合，适合实验室推广使用。

主要特点：
1.自定义光斑形状进行定点精确光刺激
2.多区域、高均匀度同时照射
3.高分辨率，可进行单细胞、多细胞和亚细胞级照射
4.兼容任何显微镜
5.外部设备触发

用户名单：
北京生命科学研究所
北京师范大学
北京师范大学
上海神经科学研究所
浙江大学
上海神经科学研究所
中科院生物物理所
深圳先进技术研究院

发表相关文章列表
[1」lYiding Li, jiamin Xu, Yafeng Liu, jJia Zhu, Nan Liu, Wenbo Zeng, Ning HuangMalte  Rasch, Haifei jiang, Xiang Gu, Xiang Li, Minhua Luo, ChengyuLi, jJunlin Teng.Jianguo Chen, Shaoqun Zeng, Longnian Lin, and Xiaohui Zhang*. A distinctentorhinal cortex to hippocampal CA1 direct circuit for olfactory associativeearning.Nature Neuroscience,2017,20:559
[2]Yuanyuan Yao, Xiaoquan Li, Baibing Zhang, Chen Yin, Yafeng Liu, Weiyu Chen,Shaoqun Zeng, jiulin Du. Visual cue-specific dopaminergic control of visuomotol
transformation and behavioralselection.Neuron,2016,89(3):598-612
[3]Su jiang, Yafeng Liu, Xiaomin Wang, Kefei Liu, Dinghong Zhang, Yiding Li.Aiping Yu,Xiaohui Zhang,Jiayi Zhang, Jianguang Xu, Yudong Gu, WendongXu,Shaoqun Zeng. Automated, highly reproducible, wide-field, ight-based corticamapping method using a commercial stereo microscope and its applicationsBiomedicalOptics Express,2016,7(9):3478-3490
[4]Kaiyu Wang, Jiaxin Gong, Qingxiu Wang, Hao Li, Qi Cheng, Yafeng LiuShaogun Zeng, Zuoren Wang. Parallel pathways convey olfactory information withopposite polarities in Drosophila. Proceeding of the National Academy of Science ofthe United States ofAmerica,2014,111:3164-3169
[5]jie Tu, Fan Yang, Jun Wan, Yunhui Liu, Jie Zhang, Bifeng Wu, Yafeng Liu.Shaoqun Zeng, Liping Wang. Liaht-controlled astrocytes promote humanmesenchymal stem cells toward neuronal differentiation and improve theneurologicaldeficitin stroke rats.Glia,2014,62:106-121
[6]Yafeng Liu, Yuan Zhao, Xiaohua Lv, Yiding Li, Xiaohui Zhang, Jie Zhang, LipingWang,Shaogun Zeng.Instrumentation of a compact random-accessphotostimulator based on acousto-optic deflectors. Review of ScientificInstruments.2012，83:25116
[7]Kaiyu Wang, Yafeng Liu, Yiding Li, Yanmeng Guo, Peipei Song, XiaohuiZhang.Shaogun Zeng and Zuoren Wang Precise spatiotemporal control of optogeneticactivation using an acousto-optic device.PLoS ONE.2011,6(12):e28468