Multi-residue Method Development Using Agilent 6475 LC/TQ System Implemented with Intelligent Optimization Software: Application to Forensic Drug Screening

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Developing Multiple Reaction Monitoring (MRM)-based screening methods for routine analysis is a common operation in analytical laboratories. Tomaximize analytical performance, researchers often need to optimize many LC and MS parameters. An intelligent software could assist method developmentfrom several aspects, such as cutting method development time, automating workflow, auto- selecting optimal parameters, tracking system to meet compliance requirement, etc.Agilent developed a new triple quadrupole LC/MS system, 6475 LC/TQ, which contains software improvements to facilitate MRM-based method optimization workflow .In this study, we demonstrated the new optimizer on developing multi-forensic drug screening methods and compared the final method to the one optimized using a previous system. Our results showed significant improvements on the software.