今天在看到一篇文章称：盐会像香烟和麻醉品一样让人上瘾 ，你相信吗？ 下面是相关标题和文章摘要 Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite
Sodium appetite is an instinct that involves avid specific intention. It is elicited by sodium deficiency, stress-evoked adrenocorticotropichormone (ACTH), and reproduction. Genome-wide microarrays in sodium-deficient mice or after ACTH infusion showed up-regulationof hypothalamic genes, including dopamine- and cAMP-regulated neuronal phosphoprotein 32 kDa (DARPP-32), dopamine receptors-1and -2, α-2C- adrenoceptor, and striatally enriched protein tyrosine phosphatase (STEP). Both DARPP-32 and neural plasticityregulator activity-regulated cytoskeleton associated protein (ARC) were up-regulated in lateral hypothalamic orexinergic neuronsby sodium deficiency. Administration of dopamine D1 (SCH23390) and D2 receptor (raclopride) antagonists reduced gratificationof sodium appetite triggered by sodium deficiency. SCH23390 was specific, having no effect on osmotic-induced water drinking,whereas raclopride also reduced water intake. D1 receptor KO mice had normal sodium appetite, indicating compensatory regulation.Appetite was insensitive to SCH23390, confirming the absence of off-target effects. Bilateral microinjection of SCH23390 (100nM in 200 nL) into rats’ lateral hypothalamus greatly reduced sodium appetite. Gene set enrichment analysis in hypothalamiof mice with sodium appetite showed significant enrichment of gene sets previously linked to addiction (opiates and cocaine).This finding of concerted gene regulation was attenuated on gratification with perplexingly rapid kinetics of only 10 min,anteceding significant absorption of salt from the gut. Salt appetite and hedonic liking of salt taste have evolved over >100million y (e.g., being present in Metatheria). Drugs causing pleasure and addiction are comparatively recent and likely reflectusurping of evolutionary ancient systems with high survival value by the gratification of contemporary hedonic indulgences.Our findings outline a molecular logic for instinctive behavior encoded by the brain with possible important translational–medicalimplications.
赛默飞实验室产品焕新计划有奖调研！
【七月征文】不一YOUNG实验“猿”
下周三开幕，iCS2024光谱大会，报名可看回放！
色谱耗材品限时大促，火热进行中！
