【Abstract】 Objective: To improve the HPLC method for determining ferulic acid(FA) in the human serum and to research FA clinical pharmacokinetics. Method: Serum concentrations of FA were determined by HPLC using methanol-water-acetic acid (40:59.7:0.3,v/v)as the mobile phase and the column packed with ODS (150mm × 4.6mm,5μm)as a fixed phase and the flow rate was 1.0 ml/min. FA was detected at 320 nm wave length. The internal standard was coumarin. The serum samples were treated by the water-boiling method.... 更多还原 【关键词】 川芎汤; 阿魏酸; 高效液相色谱; 药动学; 【Key words】 Decoction of Rhizoma Chuanxiong; Ferulic acid; HPLC; Pharmacokinetics;