【Author】 LIU Ming1,ZHANG Meng-jun1,ZHANG Li1,et al.(1.Department of Medical Laboratory Science;2.The Sixth Team of the Students′ Group,Third Military Medical Univercity,Chongqing 400038,China)
【Abstract】 Objective To establish a rapid and accurate method using ion-pair RP-HPLC for quantification of metformin in human plasma.Methods Human plasma sample was deproteinated with acetonitrile,and dichloromethane was used to extract metformin from the supernatant.The metformin and internal standard atenolol were separated with the Diamonsil(150×4.6mm,5 μm) C18 column.The mobile phase consisted of acetonitrile-0.007 5mol/L sodium dodecyl sulphate and 0.01mol/L sodium dihydrogen phosphate [30∶70(V∶V),pH ... 更多还原 【关键词】 HPLC； 盐酸二甲双胍； 阿替洛尔； 血浆； 【Key words】 HPLC； metformin； Atenolol； plasma；
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