【Abstract】 OBJECTIVE To establish an external standard HPLC method for the determination of sulfamethoxazole, sulfadiazine and trimethoprim in sulfamethoxazole,sulfadiazine and trimethoprim tablets.METHODS The chromatographic coditions were as follows: Diamonsil (TM) C 18 (5 μm, 200 mm × 4.6 mm ), acetonitrile-water-phosphoric acid(50∶50∶ 0.1 ) as mobile phase.The mobile plase contained 3.5 g of sodium laury sulfate ,flow rate was 1 mL ·min -1 ,detection wavelength was 257 nm .RESULTS The mean recoveries o... 更多还原 【关键词】 高效液相色谱法; 磺胺甲卟恶唑; 磺胺嘧啶; 甲氧苄啶; 【Key words】 HPLC; sulfamethoxazole; sulfadiazine; trimethoprim;