【Author】 ZHAO Yu-ting, XU Shi-xi, WANG Sheng-feng, ZHOU Yan-bin, TIAN Juan, RAN Li-ling, ZUO Ying, DING Jin-song (School of Pharmaceutical Sciences, Central South University ,ChangSha 410013, China)
【Abstract】 Objective To develop and validate a high-performance liquid chromatography (HPLC) method for the analysis of letrozole in human plasma and to study the relative bioavalability of letrozole dispersible tablets versus tablets. Method The liquid-liquid extraction of letrozole from plasma was performed with aether. the letrozole was chromatographed on a Diamonsil C18 column(4.6mm×200 mm, 5μm) with a mobile phase consisting of acetonitrile and phosphate buffer in the ratio of 41∶59v/v, the mobile pha... 更多还原 【关键词】 来曲唑; 高效液相色谱法; 相对生物利用度; 【Key words】 Letrozole; High-performance liquid chromatography; Relative bioactivity;