质构仪药片剪切装置

Bilayer systems typically contain an immediate-release component in one layer and the extended-release component in the other layer. However, the development and production of quality bilayer tablets is not without issues such as layer separation. The Bilayer Tablet Shear Rig provides the means to assess this problem. The bilayer tablet fits into the central cavity of a guillotine-type blade and is then compressed until the two components of the tablet are sheared apart. The shear force and distance to failure are measured. Visual characterisation of the fracture surface is necessary to quantify the percentage of each fracture failure mode. This enables manufacturers to optimise their tablet formulations for adhesion of the two tablet components.