方案摘要
方案下载应用领域 | |
检测样本 | |
检测项目 | |
参考标准 |
Chitosan and polyacrylic acid (PAA) both have weak, short-lasting bioadhesive properties; therefore, a hybrid particle composed of a chitosan derivative and PAA could be used as a new bioadhesive agent. Using simultaneous in-situ monitoring with a multidetection system, N-carboxymethyl chitosan was ionically bonded to acrylic acid and then polymerized using potassium persulphate as the initiator (N-CMCA-Dh of 165 nm). The PAA on N-CMCA was crosslinked using N,N-methylene-bisacrylamide (N-CMCAC-Dh of 141 nm). During polymerization, the solution developed a milky white appearance, and polymerization kinetics was determined to be 3.2 × 10?3 ± 4.0 × 10?6 mmol/min. The reaction for PAA alone was 1.7 times faster than that of the hybrid system. The particles showed an increase in thermal stability and reduction of thermal-mass loss compared with the N-CMC alone. The N-CMCAC particles showed the highest bioadhesion onto the stomach. The gastroprotection index of N-CMChAC particles against ethanol/HCl-induced ulcers in mice was 68.2 ± 6.4%. Similar results were observed for omeprazole (74.2 ± 5.3%). The particles obtained in this work have potential for use in drug delivery to the stomach, perhaps to aid in treating ulceration and inflammation, and can be used as a system for the prevention of ethanol-induced ulcers.
NanoBrook产品应用-12-ZetaPALS
NanoBrook产品应用-16-ZetaPALS
相关产品
NanoBrook 173Plus多角度粒度分析仪
布鲁克海文高灵敏Zeta电位分析仪ZetaPALS
布鲁克海文Zeta电位分析仪 ZetaPlus
布鲁克海文(Brookhaven)多角度粒度分析仪173Pl
EyeTech 激光光阻粒度粒形分析仪
布鲁克海文 多角度粒度及高灵敏Zeta电位分析仪 Omni
布鲁克海文高灵敏度Zeta电位及粒度分析仪90Plus PALS
布鲁克海文Zeta电位及激光粒度分析仪90Plus Zeta
布鲁克海文激光粒度仪90Plus
布鲁克海文广角动/静态激光散射仪BI-200SM
布鲁克海文多角度激光光散射(绝对分子量测定)仪MwA
布鲁克海文圆盘式离心/沉降粒度仪
布鲁克海文高灵敏在线粒度分析仪NanoDLS
布鲁克海文ACOS实时在线粒度检测系统
高浓度粒度分析仪
关注
拨打电话
留言咨询