其他null检测 | 筛查、鉴定和定量分析潜在的遗传毒性化合物-安捷伦科技(中国)有限公司

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应用领域	生物产业
检测样本	其他
检测项目
参考标准	-

This workflow is suitable for batch-to-batch sample analysis for detecting and quantifying known potential genotoxic compounds

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This study demonstrates a routine screening of drugs to identify and quantify potential genotoxic compounds. In this Application Note, we used an Agilent 6545 Q-TOF LC/MS system to acquire accurate mass data of samples containing chlorhexidine as the drug substance. Agilent MassHunter Mass Profi ler software was used to mine the data and compare different samples to generate a differential list of compounds. An accurate mass database search against the differential list identifi ed 4-chloroaniline, a potential genotoxic compound. All Ions MS/MS acquisition mode was used to confi rm 4-chloroaniline by MS/MS library matching, and quantify it using external standards. This workflow is suitable for batch-to-batch sample analysis for detecting and quantifying known potential genotoxic compounds

上一篇使用 Agilent InfinityLab 在线液相色谱系统实现对流动化学反应器中反应过程的实时监测

下一篇苯磺酸氨氯地平 USP 方法从 HPLC 转移至 UHPLC

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