预防类生物药品含量测定>核酸检测 | The Agilent Thermal Equilibration Device Increases Resolution for Oligonucleotide Analysis-安捷伦科技(中国)有限公司

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应用领域	制药/生物制药
检测样本	预防类生物药品
检测项目	含量测定>核酸
参考标准	/

Combining the Agilent 1290 Infinity II Bio LC System with the Agilent Thermal Equilibration Device for High‑Performance Oligonucleotide Analysis

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Agilent 1290 Infinity II 生物液相色谱系统
型号：1290 Infinity II Bio LC

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Due to advances in oligonucleotide synthesis and modification, modern DNA‑ or RNA‑based biopharmaceuticals can make characterization more demanding because of their increased complexity. This application note demonstrates that the Agilent Thermal Equilibration Device (TED) combined with the biocompatible Agilent 1290 Infinity II Bio LC is an excellent setup for in‑depth analysis of oligonucleotides. Using the TED with a high‑temperature LC method, the peak resolution and analysis speed can be significantly increased. Product and process

impurities can be separated and analyzed. These results show that oligonucleotide analysis can significantly benefit from the TED.

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