使用生物大分子相互作用仪MP-SPR研究病毒之间的相互作用

2016-09-13 11:33  下载量:6

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使用生物大分子相互作用仪MP-SPR研究病毒之间的相互作用:To develop cancer vaccines, a virus-peptide interaction was measured with Multi-Parametric Surface Plasmon Resonance (MP-SPR). Viruses were coated with peptides in order to increase virus immunogenicity. Oncolytic adenoviruses (OAds) were attached to the sensor surface. Tumor-specific major histocompatibility complex (MHC) peptides attachment to the OAds was measured in real-time. Modified positive polyK-SIINFEKL peptide bound to the virus surface (binding constant 2.88 x 10-6M), whereas unmodified neutral SIINFEKL peptide did not bind.

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