定向细胞运动和分裂解释早期肢芽形态发生学

2011/02/15   下载量： 10 次

方案摘要

方案下载
应用领域 生物产业
检测样本 其他
检测项目
参考标准 暂无

The vertebrate limb bud arises from lateral plate mesoderm and its overlying ectoderm. Despite progress regarding the genetic requirements for limb development, morphogenetic mechanisms that generate early outgrowth remain relatively undefined. We show by live imaging and lineage tracing in different vertebrate models that the lateral plate contributes mesoderm to the early limb bud through directional cell movement. The direction of cell motion, longitudinal cell axes and bias in cell division planes lie largely parallel to one another along the rostrocaudal (head-tail) axis in lateral plate mesoderm. Transition of these parameters from a rostrocaudal to a mediolateral (outward from the body wall) orientation accompanies early limb bud outgrowth. Furthermore, we provide evidence that Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours.

方案下载
配置单
上一篇 在一个双稳湍流涡旋火焰中，对间歇性动态的时间-频率定位
下一篇 用立体粒子成像测速(PIV)方法对空气幕帘下方站立的模特假人周围流场进行可视化研究

文献贡献者

北京欧兰科技发展有限公司
金牌会员 丨 第17年
查看全部资料
相关仪器 更多
相关方案
更多

相关产品

当前位置： 欧兰科技 方案 定向细胞运动和分裂解释早期肢芽形态发生学

关注

拨打电话

留言咨询