其他null检测 | 肺内烟雾粒子发生器的生成和输运性能的在线现场测试评价-北京欧兰科技发展有限公司

方案摘要

方案下载

应用领域	医疗/卫生
检测样本	其他
检测项目
参考标准	暂无

利用相位多普勒粒子干涉仪（PDI）对可插入肺内，在肺内部现场产生治疗效果的喷雾的装置Microjet™进行性能检测评价。

方案下载

配置单

激光相位多普勒干涉仪LDV，PDI，PDPA，PDA
型号：PDI

¥100万 - 200万
咨询

方案详情

For infants born with respiratory distress syndrome (RDS), liquid bolus delivery of surfactant administered through an endotracheal tube is common practice. While this method is generally effective, complications such as transient hypoxia, hypercapnia, and altered cerebral blood flow may occur. Aerosolized surfactant therapy has been explored as an alternative. Unfortunately, past efforts have led to disappointing results as aerosols were generated outside the lungs with significant pharyngeal deposition and minimal intrapulmonary instillation.
A novel aerosol generator (Microjet™) is evaluated herein for intrapulmonary aerosol generation within an endotracheal tube and tested with Curosurf and Infasurf surfactants.
Compared with other aerosol delivery devices, this process utilizes low air flow (range 0.01-0.2 L/min) that is ideal for limiting potential barotrauma to the premature newborn lung. The mass mean diameter (MMD) of the particles for both tested surfactants was less than 4 μm, which is ideal for both uniform and distal lung delivery. As an indicator of phospholipid function, surfactant surface tension was measured before and after aerosol formation; with no significant difference. Moreover, this device has an outside diameter of <1mm, which permits insertion into an endotracheal tube (of even 2.0 mm). In the premature infant where intravenous access is either technically challenging or difficult, aerosol drug delivery may provide an alternative route in patient resuscitation, stabilization and care. Other potential applications of this type of device include the delivery of nutrients, antibiotics, and analgesics via the pulmonary route.

上一篇在一个双稳湍流涡旋火焰中，对间歇性动态的时间-频率定位

下一篇用大尺度层析PIV研究平移球体的空气动力学阻力

文献贡献者

北京欧兰科技发展有限公司

金牌会员丨第17年

查看全部资料