Elafin, Human, ELISA kit|Hycult HK318-01|1 x 96 det.|HK318-01-上海叶舟生物科技有限公司

产品详情

产品名称：Elafin, Human, ELISA kit

产地：Hycult

产品货号：HK318-01

产品规格：1 x 96 det.

产品说明：

Description: Elafin (Trappin-2), Human, ELISA kit

Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2 in a recent classification. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and in addition it is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including those of hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. The full-length protein is translated as a 12.3 kDa protein of 117 amino acids termed pre-elafin or Trappin-2. Cleavage of the signal peptide yields a mature protein with a molecular mass of 9.9 kDa. The 9.9 kDa secreted protein is the major form found in culture medium. In skin extracts a 6 kDa form comprising the 57 most C-terminal amino acids is present, which is the form of elafin originally described by Wiedow et al. In serum both the 9.9 and the 6 kDa form appear to be present. In urine only the short 6 kDa form is found. The HYCULT BIOTECH ELISA is not suitable to measure the short 6 kDa form. Elafin has been used as a quantitative marker for disease activity in severe psoriasis during treatment with cyclosporin. In serum/plasma of healthy individuals approximately 10-50 ng/ml elafin is present. Elafin shows a 10-fold increase in concentration during psoriasis. The determination of lafine is not disturbed by the presence of the short 6 kDa form.

Elafin, Human, ELISA kit|Hycult HK318-01由上海叶舟生物科技有限公司为您提供，货号HK318-01，规格：1 x 96 det.，CAS号：，如您想了解更多关于Elafin, Human, ELISA kit|Hycult HK318-01价格、Elafin, Human, ELISA kit|Hycult HK318-01结构式、批发、用途等信息，欢迎咨询。除供应Elafin, Human, ELISA kit|Hycult HK318-01外，还可为您提供其他等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海叶舟客户服务电话，售前、售后均可联系。

关注

拨打电话

留言咨询

供货周期：	现货
品牌：
型号：	1 x 96 det.
货号：	HK318-01