Elastase, Human, ELISA kit|Hycult HK319-01|1 x 96 det.|HK319-01-上海叶舟生物科技有限公司

产品详情

产品名称：Elastase, Human, ELISA kit

产地：Hycult

产品货号：HK319-01

产品规格：1 x 96 det.

产品说明：

Description: Elastase, Human, ELISA kit

Neutrophil elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition, mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4. In plasma of healthy individuals approx. 55 ng/ml (29 - 86 ng/ml) elastase is present.

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