方案摘要
方案下载应用领域 | 制药/生物制药 |
检测样本 | 化药制剂 |
检测项目 | 理化性质>旋光度 |
参考标准 | 无 |
An emission line of light source such as a sodium lamp or a mercury lamp is usually used to measure the optical rotation of pharmaceutical products. However, the Japanese Pharmacopeia and the European Pharmacopeia only mention the use of a sodium lamp as the light source. A polarimeter using a halogen lamp and a band pass filter (BPF) can also be used, as mentioned in the United States Pharmacopeia. However, the measurement error from the transmission property, that is the difference between the center wavelength of the BPF and the wavelength of emission line, cannot be avoided. Herein, the optical rotation of pirarubicin was measured using a sodium lamp and a halogen lamp, and the measurement error between the results was evaluated.
An emission line of light source such as a sodium lamp or a mercury lamp is usually used to measure the optical rotation of pharmaceutical products. However, the Japanese Pharmacopeia and the European Pharmacopeia only mention the use of a sodium lamp as the light source. A polarimeter using a halogen lamp and a band pass filter (BPF) can also be used, as mentioned in the United States Pharmacopeia. However, the measurement error from the transmission property, that is the difference between the center wavelength of the BPF and the wavelength of emission line, cannot be avoided. Herein, the optical rotation of pirarubicin was measured using a sodium lamp and a halogen lamp, and the measurement error between the results was evaluated.
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