上交大吕海涛|功能代谢组科学实验室成立六周年啦!

　　Laboratory for Functional Metabolomics Science (LFMS) (功能代谢组科学实验室) is at The Frontiers of Functional Metabolomics Toward The Interdisciplinary Sciences of Life and Health

功能代谢组科学实验室 (LFMS)主体依托上海交大系统生物医学研究院/系统生物医学教育部重点实验室吕海涛课题组主体依托上海交通大学系统生物医学研究院，系统生物医学教育部重点实验室和系统生物医学111引智计划等一流科研设施平台，目前建有完善的组学分析平台、细胞生物学平台、细胞与动物实验设施，生物信息学分析平台等。近五年，实验室在国家重点研发计划，国家自然科学基金、上海自然科学基金，国家转化医学研究中心和上海交通大学，上海市院士专家工作站(专家级)，安捷伦科技(中国)，SCIEX中国和鹿明生物科技等基金项目支持下，重点开展面向生命健康科学交叉应用的下一代功能代谢组学研究(Spatial Temporal Operative Real Metabolomics-STORM 和Spatial Temporal Operative Real Metabolomics Plus-STORM+)。主要围绕功能代谢组学理论与方法学创新，及其生命健康交叉科学领域的微生物源/中药源功能天然产物的治疗发现等关键科学问题，开展了系列探索性研究工作，主要在如下三方面取得阶段性新进展：1) 创新功能代谢组学理论与方法学; 2) 基于功能代谢组学阐明微生物铁载体的新功能和生物膜形成的新机理;3) 基于功能代谢组学革新肝胆胰疾病诊断与解析天然产物治疗疾病的新机制。

　　Laboratory for Functional Metabolomics Science (LFMS)has been mostly focusing on the method innovations and translational applications of functional metabolomics in the interdisciplinary sciences of life and health. The track-record of the LFMS can be summarized as the follows: 1) definition and development of novel methods and strategies of functional metabolomics, such as precision-modification metabolomics and spatial temporal operative real metabolomics (STORM). 2) elucidation of the new regulatory-mechanism of siderophore biosynthesis on the virulence formation of pathogenic Escherichia coli; 3) clarification of novel mechanism of biofilm formation in pathogenic Escherichia coli at a functional-metabolism level, conserving novel strategy to tangle all the harmful impact of biofilms by targeting functional metabolites, which are extremely threaten-microorganisms mostly account for high-frequency drug resistance, air pollution and food contamination. 4) identification of novel metabolite biomarkers that can facilitate the diagnosis and metastasis monitoring of pancreatic cancer, as well as characterization of novel metabolic targets for disease therapeutic discovery. Currently, LFMS further studies the novel methods of next-generation functional metabolomics (STORM+) aiming at promoting the interdisciplinary applications of life and health sciences by the discovery of poly-functional metabolites in a diversity of biological matrixes .

　　Over the past five years, based on these research findings on functional metabolomics and its translational applications in the interdisciplinary sciences of life and health, LFMS has successfully secured many national competitive research grants from The National Natural Science Foundation of China and The Ministry of Science and Technology of People’s Republic of China, as well five competitive research grants from different funding agencies. As a corresponding author, LFMS Faculty Director Dr. Haitao Lu has published 58 peer reviewed papers in many high-profile journals. Dr. Lu has delivered 40 invited presentations and plenary lectures in International/national conferences, and overseas top-ranking institutions.

　　In terms of academic achievements and impactful contribution in the field of functional metabolomics and its translational applications in the interdisciplinary sciences of life and health, Dr. Lu was elected as a fellow of The Royal Society of Chemistry in UK (FRSC), a fellow of The Royal Society of Biology in UK (FRSB), a fellow of Linnean Society of London in UK (FLS), and an vice secretary general, Metabolomics Committee Biophysical Society of China. In addition, Dr Lu actively participates in public service by providing peer-review support, knowledge exchanging, and scholar-Insight, who has been invited to be a faculty member (chemical biology)- Faculty Opinions Prime (Former F1000 Prime), an academic membership for Editorial Board of many peer-reviewed journals: Pharmacological Research (Section Editor, Q1, TOP), Phytomedicine (Ex-Associate Editor, Q1, TOP), Royal Society Open Science (Q1, Associate Editor), Chinese Medicine (Q1, Associate Editor), Proteomics(Q1, EBM), APSB (Q TOP, Young EBM), JAT, as well as act as peer-reviewed expert for National Natural Science Foundation of China, NHMRC in Australia and Health and Medical Research Fund (HMRF) in Hong Kong, and more than 30 high-impact journals.

　　Faculty Director/Principal Investigator

　　吕海涛博士，上海交通大学系统生物医学研究院/系统生物医学教育部重点实验室研究员(长聘教席)/博士生导师, 英国皇家化学会会士(FRSC), 英国皇家生物学会会士(FRSB)，伦敦林奈学会会士(FLS), TALENT-100和绿色通道引进高层次人才，Faculty Opinions (F1000 Prime)Faculty 专家，澳门科技大学兼职教授/博导，功能代谢组科学实验室主任, 上海院士专家工作站(专家级) 首席专家。主要研究方向：生命健康交叉应用驱动的下一代功能代谢组学研究(STORM和STORM+)。先后主持国家重点研发计划课题等10多项课题;权威杂志发表SCI检索论文58篇;任中国生物物理学会代谢组学分会副秘书长等，Pharmacological Research-Section主编和Royal Society Open Science 副主编等;安捷伦科技ACT-UR奖获得者。