供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL0290R |
CAS号: |
Quantity size:
0.2ml
Concentration:
1mg/ml 胰岛素受体β抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic胰岛素受体β抗体 enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.
Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the 胰岛素受体β抗体insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
胰岛素受体β抗体Also known as:
CD 220; CD220; CD220 antigen; HHF 5; HHF5; HIR B; INSR; INSR; Insulin receptor; Insulin receptor subunit beta; IR; INSR_HUMAN.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, .
●
Immunogen: KLH conjugated synthetic peptide derived from human IR beta.
●
胰岛素受体β抗体Predicted Molecular Weight: 68kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl548Ra01细胞间粘附分子1(ICAM1)多克隆抗体Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1)
kl548Rb51细胞间粘附分子1(ICAM1)多克隆抗体Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1)
kl549Hu01角蛋白9(KRT9)多克隆抗体Polyclonal Antibody to Keratin 9 (KRT9)
kl549Mu01角蛋白9(KRT9)多克隆抗体Polyclonal Antibody to Keratin 9 (KRT9)
kl551Bo01碱性成纤维细胞生长因子(FGF2)多克隆抗体Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)
kl551Ga01碱性成纤维细胞生长因子(FGF2)多克隆抗体Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)
kl551Hu01碱性成纤维细胞生长因子(FGF2)多克隆抗体Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)
kl551Mu01碱性成纤维细胞生长因子(FGF2)多克隆抗体Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)
kl551Po01碱性成纤维细胞生长因子(FGF2)多克隆抗体Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)
kl551Ra01碱性成纤维细胞生长因子(FGF2)多克隆抗体Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)
kl551Rb52碱性成纤维细胞生长因子(FGF2)多克隆抗体Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)
kl552Bo01组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl552Ca01组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl552Eq01组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl552Hu01组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl552Mu01组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl552Po01组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl552Ra01组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl552Rb52组织金属蛋白酶抑制因子1(TIMP1)多克隆抗体Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
kl553Ca01基质金属蛋白酶9(MMP9)多克隆抗体Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9)
kl553Hu01基质金属蛋白酶9(MMP9)多克隆抗体Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9)
kl553Mu01基质金属蛋白酶9(MMP9)多克隆抗体Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9)
kl553Po01基质金属蛋白酶9(MMP9)多克隆抗体Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9)
kl553Ra01基质金属蛋白酶9(MMP9)多克隆抗体Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9)
kl554Ra01尼克酰胺腺嘌呤二核苷酸磷酸氧化酶1(NOX1)多克隆抗体Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 (NOX1)
kl556Hu01角蛋白7(KRT7)多克隆抗体Polyclonal Antibody to Keratin 7 (KRT7)
kl557Hu01甲状腺过氧化物酶(TPO)多克隆抗体Polyclonal Antibody to Thyroid Peroxidase (TPO)
相关产品
关注
拨打电话
留言咨询