1, Optimization of culture conditions to enhance cis-epoxysuccinate hydrolase production in Escherichia coli by response surface methodology Biochemical Engineering Journal, Volume 42, Issue 2, 1 November 2008, Pages 133-138 Haifeng Pan, Zhipeng Xie, Wenna Bao, Jianguo Zhang 2,Response surface methodological approach for optimization of enzymatic synthesis of sorbitan methacrylate Enzyme and Microbial Technology, Volume 39, Issue 3, 3 July 2006, Pages 381-386 Gwi-Taek Jeong, Don-Hee Park 3, Response surface methodological analysis on biohydrogen production by enriched anaerobic cultures Enzyme and Microbial Technology, Volume 38, Issue 7, 2 May 2006, Pages 905-913 Yang Mu, Gang Wang, Han-Qing Yu 4, Optimization of alkaline protease production by batch culture of Bacillus sp. RKY3 through Plackett–Burman and response surface methodological approaches Bioresource Technology, Volume 99, Issue 7, May 2008, Pages 2242-2249 L.V.A. Reddy, Young-Jung Wee, Jong-Sun Yun, Hwa-Won Ryu 5, Optimization of media composition for Nattokinase production by Bacillus subtilis using response surface methodology Bioresource Technology, Volume 99, Issue 17, November 2008, Pages 8170-8174 V. Deepak, K. Kalishwaralal, S. Ramkumarpandian, S. Venkatesh Babu, S.R. Senthilkumar, G. Sangiliyandi 谢谢