【作者】：Tsung-Hsien Chou†, Jih-Jung Chen‡, Shiow-Ju Lee§, Michael Y. Chiang#, Cheng-Wei Yang§ and Ih-Sheng Chen*† 【题名】：Cytotoxic Flavonoids from the Leaves of Cryptocarya chinensis 【期刊】：J. Nat. Prod., Article ASAP 【年、卷、期、起止页码】：August 12, 2010 【摘要】：Bioassay-guided fractionation led to the isolation of six new tetrahydroflavanones, cryptochinones A−F (1−6), from the neutral CHCl3 fraction of Cryptocarya chinensis leaves, together with 14 known compounds (7−20). The structures of these new compounds were determined through spectroscopic analyses, including 2D-NMR, MS, CD, and X-ray crystallographic analysis. Among the isolates, infectocaryone (7) showed cytotoxic activities with IC50 values of 11.0 and 3.7 μM against NCI-H460 and SF-268 cell lines, respectively, and cryptocaryanone A (9) showed cytotoxic activities with IC50 values of 5.1, 4.3, and 5.0 μM against MCF-7, NCI-H460, and SF-268 cell lines, respectively. 【链接】：http://pubs.acs.org/doi/pdfplus/10.1021/np100014j
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