在细胞水平上用共聚焦显微PIV方法研究高压积红细胞流动的近壁不稳定性

2012/01/14   下载量： 4 次

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应用领域 医疗/卫生
检测样本 全血/血清/血浆
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参考标准 暂无

In hemodynamics, the inherent intermittency of two-phase cellular-level flow has received little attention. Unsteadiness is reported and quantified for the first-time in the literature using a combination of fluorescent dye labelling, time-resolved scanning confocal microscopy, and micro-particle image velocimetry (μPIV). The near-wall red blood cell (RBC) motion of physiologic high-hematocrit blood in a rectangular microchannel was investigated under pressure driven flow. Intermittent flow was associated with (1) the stretching of RBCs as they passed through RBC clusters with twisting motions; (2) external flow through local obstacles; and (3) transitionary rouleaux formations. Velocity profiles are presented for these cases. Unsteady flow clustered in local regions. Extra-cellular fluid flow generated by individual RBCs was examined using submicron fluorescent microspheres. The capabilities of confocal μPIV post-processing were verified using synthetic raw PIV data for validation. Cellular interactions and oscillating velocity profiles are presented and 3D data are made available for computational model validation.

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北京欧兰科技发展有限公司
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