采用拉格朗日相干结构方法建立左心室流动和血栓栓塞风险的关联模型

2017/02/13   下载量： 20 次

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应用领域 生物产业
检测样本 其他
检测项目
参考标准 暂无

采用LaVision公司的PIV系统。测量左心室模型的流动情况，并研究流场特征和发生血栓栓赛风险的关系。建立两者之间的关联模型。

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A thrombus is a blood clot that forms on a surface, and can grow and detach, presenting
a high risk for stroke and pulmonary embolism. This risk increases with blood-contacting medical
devices, due to the immunological response to foreign surfaces and altered flow patterns that activate
the blood and promote thromboembolism (TE). Abnormal blood transport, including vortex behavior
and regional stasis, can be assessed from Lagrangian Coherent Structures (LCS). LCS are flow
structures that bound transport within a flow field and divide the flow into regions with maximally
attracting/repelling surfaces that maximize local shear. LCS can be identified from finite time
Lyapunov exponent (FTLE) fields, which are computed from velocity field data. In this study, the goal
was to use FTLE analysis to evaluate LCS in the left ventricle (LV) using velocity data obtained from
flow visualization of a mock circulatory loop. A model of dilated cardiomyopathy (DCM) was used to
investigate the effect of left ventricular assist device (LVAD) support on diastolic filling and transport
in the LV. A small thrombus in the left ventricular outflow tract was also considered using data from
a corresponding LV model. The DCM LV exhibited a direct flow of 0.8 L/cardiac cycle, which was
tripled during LVAD support Delayed ejection flow was doubled, further illustrating the impact of
LVAD support on blood transport. An examination of the attracting LCS ridges during diastolic filling
showed that the increase is due primarily to augmentation of A wave inflow, which is associated with
increased vortex circulation, kinetic energy and Forward FTLE. The introduction of a small thrombus
in the left ventricular outflow tract (LVOT) of the LV had a minimal effect on diastolic inflow, but
obstructed systolic outflow leading to decreased transport compared with the unobstructed LVOT
geometry. Localized FTLE in the LVOT increased dramatically with the small thrombus model, which
reflects greater recirculation distal to the thrombus location. The combination of the thrombus and
the LVAD increased stasis distal to the thrombus, increasing the likelihood of recurring coagulation
during Series flow conditions. The extension of the results of the previous studies with this analysis
provides a more sensitive indicator of TE risk than the Eulerian velocity values do, and may provide
an important tool for evaluating medical device design, surgical implantation, and treatment options.

上一篇 在一个双稳湍流涡旋火焰中，对间歇性动态的时间-频率定位
下一篇 粗糙壁面边界层的亚微米分辨长工作距离显微PIV测量

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北京欧兰科技发展有限公司
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