方案摘要
方案下载应用领域 | 医疗/卫生 |
检测样本 | 其他 |
检测项目 | |
参考标准 | 暂无 |
立陶宛Ekspla公司生产的光学参量振荡器,型号NT342A,重复频率10赫兹。脉冲宽度5纳秒。输出波长420-2300纳米。实验中采用的近红外激光峰值功率2千瓦,单脉冲能量1-15微焦。以此为光源,对人内耳蜗的原位声光模拟进行了研究分析。
Intracochlear optical stimulation has been suggested as an alternative approach to hearing prosthetics in recent years. This study investigated the properties of a near infrared laser (NIR) induced optoacoustic effect. Pressure recordings were performed at the external meatus of anaesthetized guinea pigs during intracochlear NIR stimulation. The sound pressure and power spectra were determined. The results were compared to multi unit responses in the inferior colliculus (IC). Additionally, the responses to NIR stimulation were compared to IC responses induced by intracochlear electric stimulation at the same
cochlear position to investigate a potentially confounding contribution of direct neural NIR stimulation.The power spectra of the sound recorded at the external meatus (n ¼ 7) had most power at frequencies below 10 kHz and showed little variation for different stimulation sites. The mean spike rates of IC units responding to intracochlear NIR stimulation (n ¼ 222) of 17 animals were significantly correlated with the power of the externally recorded signal at frequencies corresponding to the best frequencies of the IC units. The response strength as well as the sound pressure at the external meatus depended on the pulse peak power of the optical stimulus. The sound pressure recorded at the external meatus reached levels
above 70 dB SPL peak equivalent. In hearing animals a cochlear activation apical to the location of the fiber was found. The absence of any NIR responses after pharmacologically deafening and the comparison to electric stimulation at the NIR stimulation site revealed no indication of a confounding direct neural NIR stimulation. Intracochlear optoacoustic stimulation might become useful in combined electro-acoustic stimulation devices in the future.
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