脉冲流场在USP溶解仪中引起的水动力复杂性

2019/12/03   下载量： 0 次

方案摘要

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应用领域 石油/化工
检测样本 其他
检测项目 其他
参考标准 暂无

采用LaVison公司的DaVis软件平台，通过阴影发成像和粒子成像测速分析，对脉冲流场在USP溶解仪中引起的水动力复杂性，进行了研究。

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USP dissolution Apparatus 4 can have a pulsing or non-pulsing flow, with most commercial apparatus employing a pulsing flow. Overall, a low velocity flow field is present, particularly in the larger 22.6-mm diameter cell. Dissolution data, computational fluid dynamics (CFD), and imaging methods are used and discussed to investigate the effects of low velocity pulsing flow on dissolution. Local velocity patterns, density gradients, and the effect of flow rate on particulate dispersion can all contribute to the observed dissolution rate. In silico simulation tools and imaging techniques have proved useful in determining local hydrodynamics and, in some cases, their effect on observed dissolution rates. Methods to investigate concentration gradients at the dissolving surface are required to investigate further the effect
of hydrodynamics on the dissolution process. In conclusion, it is necessary to take local flow patterns and velocities into
account, rather than overall flow rate alone, when interpreting dissolution rate data in the flow-through apparatus.

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北京欧兰科技发展有限公司
金牌会员 丨 第17年
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