U0126 |1MG|662005-1MG-上海叶舟生物科技有限公司

产品详情

产品编号： 662005-1MG
产品名称： U0126
供应商： Merck
规格： 1MG
目录价： 1039
库存状态：现货
CAS编号： 109511-58-2
相关信息： 662005 U0126
1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene
A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Shown to block doxazosin-induced osteoblastic differentiation. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Noncompetitive with respect to ATP. Also available in InSolution™ format (Cat. No. 662009).
产品信息
Form White solid
Primary Target MEK1
Primary Target IC50 72 nM
Secondary target MEK2 (IC50 = 58 nM)
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Chemical formula C18H16N6S2•½C2H5OH
CAS number 109511-58-2
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
保存条件： -20°C

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