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Itraconazole発行日:2013年7月発行人:株式会社資生堂7(7乃(I)X事業部 伊曲康唑 伊曲康唑是三氮唑类抗真菌药。主要通过阻碍细胞膜的生合成来杀死真菌。除了作为外用涂抹药来治疗难以治愈的灰指甲和脚气等外表皮肤真菌病之外,还被用作消化器真菌病和呼吸器真菌病等等脏真菌病的治疗。以下是按照日本药局方的纯度实验方法,使用 CAPCELLPAK C18 MGII S3 (4.6 mmi.d.x100mm)对其进行分析的结果。 Itraconazole, one of the azole antifungal drugs, is known to inhibit biosynthesis ofcell membrane of fungi. It’s used to treat athlete’s foot in nails, which is difficult to cure withusual ointments, and other superficial mycoses, such as mycoses of gastrointestinal andrespiratory organs. 5Shown below is a chromatogram obtained according to a purity test ofthe Japanese Pharmacopeia, with CAPCELL PAK C18 MGII S3 (4.6 mm i.d. x 100 mm). 5 10 15 20 25 30 [min] 【HPLC Conditions】 Column : CAPCELL PAK C18 MGII S3 ; 4.6 mm i.d. x 100 mm Mobile phase :A) Tetrabutylammonium hydrogen sulfate(17→625) B) CH3CN →20%(25.1 min) Gradient Flow rate : 1.5 mL/min Temperature :35℃ Detection : UV 225 nm Inj.vol. :10 pL Sample dissolved in :CH3OH/THF=50/50 (Miconazole nitrate and Itraconazole, 50 ug/mL each)
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三耀精细化工品销售(北京)有限公司为您提供《伊曲康唑中纯度检测方案(液相色谱柱)》,该方案主要用于原料药中限度检查检测,参考标准《暂无》,《伊曲康唑中纯度检测方案(液相色谱柱)》用到的仪器有null。
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