【资料】Toxicology for Non-Toxicologists

可以打开的呀，下面是此书的部分目录：

Contents

List of Figures and Tables ................................................................................. vii
Preface and Acknowledgments ......................................................................... ix

Chapter 1
Introduction ................................................................................. 1

Chapter 2
Everyday Applications of Toxicology ....................................... 5

Food Toxicology.............................................................................................. 7
Examples of Pollution Incidents ................................................................. 13
Media Reporting of Toxicology................................................................... 19
Limitations of Our Current Knowledge...................................................... 22

Chapter 3
Essential Concepts of Toxicology........................................... 25

Exposure ........................................................................................................ 26
Mechanisms of Toxic Action....................................................................... 32
Species Variability ........................................................................................ 35
Dose Response.............................................................................................. 35

Chapter 4
Types of Toxic Effects .............................................................. 41

Cancer ............................................................................................................ 41
Unknowns ...................................................................................................... 49
Non-Cancer Effects in Humans ................................................................... 49
Ecological Effects.......................................................................................... 53

Chapter 5
Estimation of Toxic Effects ...................................................... 57

Regulatory Framework................................................................................. 57
Laboratory Animal Studies ......................................................................... 61
General Guidelines ....................................................................................... 65

iii
Cancer Studies .............................................................................................. 66
Reproductive Studies................................................................................... 67
Developmental Studies ................................................................................ 68
In Vitro Methods ........................................................................................... 68
Human Clinical Studies ................................................................................ 69
Epidemiology................................................................................................. 70

Chapter 6
Important Toxicological Parameters ....................................... 73

Toxicokinetics ............................................................................................... 73
Species Differences....................................................................................... 84
Genetics ......................................................................................................... 85
Kinetics/Metabolism .................................................................................... 86
Sex and Hormonal Status ............................................................................ 86
Nutrition and Dietary Factors.......................................................................87
Age.................................................................................................................. 87
Physiology ..................................................................................................... 88
Selection of Toxic Endpoints ...................................................................... 89