影子
第3楼2009/10/17
可以打开的呀,下面是此书的部分目录:
Contents
List of Figures and Tables ................................................................................. vii
Preface and Acknowledgments ......................................................................... ix
Chapter 1
Introduction ................................................................................. 1
Chapter 2
Everyday Applications of Toxicology ....................................... 5
Food Toxicology.............................................................................................. 7
Examples of Pollution Incidents ................................................................. 13
Media Reporting of Toxicology................................................................... 19
Limitations of Our Current Knowledge...................................................... 22
Chapter 3
Essential Concepts of Toxicology........................................... 25
Exposure ........................................................................................................ 26
Mechanisms of Toxic Action....................................................................... 32
Species Variability ........................................................................................ 35
Dose Response.............................................................................................. 35
Chapter 4
Types of Toxic Effects .............................................................. 41
Cancer ............................................................................................................ 41
Unknowns ...................................................................................................... 49
Non-Cancer Effects in Humans ................................................................... 49
Ecological Effects.......................................................................................... 53
Chapter 5
Estimation of Toxic Effects ...................................................... 57
Regulatory Framework................................................................................. 57
Laboratory Animal Studies ......................................................................... 61
General Guidelines ....................................................................................... 65
iii
Cancer Studies .............................................................................................. 66
Reproductive Studies................................................................................... 67
Developmental Studies ................................................................................ 68
In Vitro Methods ........................................................................................... 68
Human Clinical Studies ................................................................................ 69
Epidemiology................................................................................................. 70
Chapter 6
Important Toxicological Parameters ....................................... 73
Toxicokinetics ............................................................................................... 73
Species Differences....................................................................................... 84
Genetics ......................................................................................................... 85
Kinetics/Metabolism .................................................................................... 86
Sex and Hormonal Status ............................................................................ 86
Nutrition and Dietary Factors.......................................................................87
Age.................................................................................................................. 87
Physiology ..................................................................................................... 88
Selection of Toxic Endpoints ...................................................................... 89