第3楼2003/08/26
六、新型膜柱混合型电化学自动再生抑制器的主要特点
1.采用膜柱混合型比单纯膜抑制器的化学抑制能力和抑制容量大得多，有很高的抑制效率，可大大降低电导背景值，提高分析的灵敏度。精选牢固型离子交换膜，使抑制器的使用寿命得到极大的延长。
2.化学抑制与电化学自动连续再生的原理，对于阴离子分析系统，流动相中的HCO3-和CO32-与H+型阳离子交换树脂和树脂膜反应生成低电导的H2CO3相，而分析屋则与树脂相的H+形成高电导的HX，这样就使待测离子的相对电导信号大大提高，从而提高分析的灵敏度和选择性。
对于阳离子分析系统，流动相中的H+与OH-型的阴离子交换树脂和树脂膜反应生成不电离的H2O，而分析物则形成高电导的MOH，从而提高分析物的电导信号，即分析的灵敏度，分析的选择性和可靠性也得到提高。
利用电解水的原理使抑制器中的树脂得到自动连续再生，即使阳离子交换树脂不断氢型化，阴离子交换树脂不断OH型化。抑制器内置电流显示和电流调节装置，可方便的控制电化学再生过程。
3.用淋出液作电解液，不需另配再生液，也不增加输液装置，这样就简化了再生流路。
4.将化学抑制器与电导检测池集成在一起，这样就缩短了抑制器和检测池之间的距离，减少了液流中产生气泡的几率，抑制了色谱峰的分散，提高了测定的灵敏度，一体化结构也便于用户使用和控制。
七、关于膜柱混合型电化学抑制器与微膜抑制器性能的比较
膜柱混合型电化学抑制器是我公司在多年研究试验基础上开发的新一代离子色抑制系统，它与旧式的微膜抑制器相比，有以下几个突出的优点：
1、它比微膜抑制器省去了再生液系统（包括蠕动泵、再生液及其连接管路），只使用单一淋洗液，使抑制系统更加简化，操作更加方便。
2、膜柱混合型抑制器比微膜抑制器抑制能力更强，它通过内置可调旋钮调节电解电流（内置电流表头，使其可视化），利用淋洗液废液回流自动电解再生抑制系统背景电导，使其抑制范围更广、抑制能力更强，对要求使用浓度比较大淋洗液的色谱柱来说无疑是一个喜讯。
3、微膜抑制器它和电导池是分离的，不可避免的要用管路连接，使其死体积很大，灵敏度自然降低，数据误差大；而现在的膜柱混合型电化学抑制器把电导池做到了抑制器里面，是其死体积几乎达到零，灵敏度高，数据准确，稳定性好。
4、它应用进口树脂膜，比起微膜抑制器更加不容易损坏，使其寿命大大延长，免去了微膜抑制器担心膜被损坏的后顾之忧，使其更加稳定、可靠，得到广大用户的青睐。
5、它还是目前国内最先进的抑制系统，紧跟国际步伐，与世界先进科技同步前进。
第10楼2003/11/27
所谓双抑制,是美国Alltech的技术,我们两年前就已经用过这个技术.但问题是
1.双抑制的价格比戴安的抑制还要高,
2.流路十分复杂,易漏
3.抑制后需要脱气,还要分流,峰扩散严重,同一根色谱柱可能会柱效会失去三分之一或更多,
4.抑制容量不高,只能用于低浓度的淋洗液,
因此总体而言,比不上戴安的抑制器,也没有价格优势.
下面的戴安公司和万通在美国的专利(国际性的大公司会在全世界都申请专利,特别是美国)
Dionex的US专利
PAT. NO. Title
1 6,623,630 Method and apparatus for monitoring a fluid system
2 6,610,546 Continuous electrolytically regenerated packed suppressor for ion chromatography
3 6,562,628 Electrolytic suppressor and separate eluent generator combination
4 6,508,985 Continuous electrolytically regenerated packed bed suppressor for ion chromatography
5 6,495,371 Continuous electrolytically regenerated packed bed suppressor for ion chromatography
6 6,436,719 Displacement chemical regeneration method and apparatus
7 6,425,284 Method and apparatus for gas-assisted suppressed chromatography
8 6,328,885 Current-efficient suppressors
9 6,325,976 Continuous electrolytically regenerated packed bed suppressor for ion chromatography
10 6,316,271 Acid or base generator and method of use
11 6,316,270 Acid base or generator
12 6,315,954 Acid or base generator and analyzer
13 6,248,798 Anion-exchange resins including ion-exchange groups with at least two nitrogen groups, and methods of making and using same
14 6,225,129 Large capacity acid or base generation apparatus and method of use
15 6,077,434 Current-efficient suppressors and method of use
16 6,074,541 Preformed polymer coating process and product
17 6,045,846 Produce sterilization
18 6,036,921 Acid or base generator with chromatograph
19 6,027,643 Ion chromatographic method and apparatus using a combined suppressor and eluent generator
20 6,001,081 Kink inhibiting device
21 5,968,363 Bifunctional crown ether-based cation-exchange stationary phase for liquid chromatography
22 5,936,003 Hydrolytically stable resins for use in anion-exchange chromatography
23 5,925,253 Hydrolytically stable resins for use in anion-exchange chromatography
24 5,914,025 Ion chromatographic method and apparatus using ion reflux
25 5,865,994 Bifunctional crown ether-based cation-exchange stationary phase for liquid chromatography
26 5,843,311 Accelerated solvent extraction method
27 5,801,302 Multicycle loop injection for trace analysis by ion chomatography apparatus and method
28 5,792,331 Preformed polymer coating process and product
29 5,785,856 Automated accelerated solvent extraction apparatus and method
30 5,773,615 Intermittent electrolytic packed bed suppressor regeneration for ion chromatography
31 5,739,422 Multicycle loop injection for trace analysis by ion chromatography apparatus and method
32 5,667,657 Pressure injection apparatus and method for injecting a sample into an electrophoresis capillary
33 5,660,727 Automated analyte supercritical fluid extraction apparatus
34 5,647,976 High pressure and temperature cell for solvent extraction
35 5,633,171 Intermittent electrolytic packed bed suppressor regeneration for ion chromatography
36 5,616,227 Method for extending the life of electrophoretic gels
37 5,597,734 Ion chromatography using frequent regeneration of batch-type suppressor
38 5,597,481 Electrochemical pretreatment system for liquid sample analysis
39 5,571,725 Method for precipitation of insoluble salts in divalent ion-form materials
40 5,569,365 Intermittent electrolytic membrane suppressor regeneration for ion chromatography
41 5,532,279 Ion-exchange composition employing resin attachment to dispersant and method for forming the same
42 5,518,622 Electrochemical pretreatment system for liquid sample analysis
43 5,457,626 Bimodal liquid chromatography pump employing artificial intelligence logic feedback control
44 5,441,613 Methods and apparatus for real-time monitoring, measurement and control of electroosmotic flow
45 5,352,360 Ion chromatography system using electrochemical suppression and detector effluent recycle
46 5,324,752 Ion-exchange composition employing resin attachment to dispersant and method for forming the same
47 5,316,630 Methods for chromatography analysis
48 5,296,115 Method and apparatus for improved detection of ionic species by capillary electrophoresis
49 5,271,903 Supercritical fluid extraction restrictor and collection system
50 5,248,426 Ion chromatography system using electrochemical suppression and detector effluent recycle
PAT. NO. Title
51 5,045,204 Method and apparatus for generating a high purity chromatography eluent
52 4,999,098 Modified membrane suppressor and method for use
53 4,839,788 Bipolar voltage to frequency converter
54 4,751,189 Method for balancing background conductivity for ion chromatography
55 4,700,059 Chromatographic optical detector with logarithmic calibration circuit
56 4,644,807 Fluid sample delivery apparatus
57 4,512,545 Externally actuated valve assembly and method
58 4,486,312 Analysis of liquid streams using tubing with protuberances on its inner wall
59 4,482,967 Conductivity detector and method
60 4,455,233 Method and apparatus for ion analysis and detection using reverse mode suppression
61 4,376,047 Coated resin ion exchange composition
62 4,351,909 High performance ion-exchange composition
63 4,314,823 Combination apparatus and method for chromatographic separation and quantitative analysis of multiple ionic species
64 4,265,634 Chromatographic separation and quantitative analysis of ionic species
65 4,242,097 Method and apparatus for quantitative analysis of weakly ionized anions or cations
66 4,148,705 Gas plasma reactor and process
67 4,127,437 Process for etching SiO.sub.2 utilizing HF vapor and an organic catalyst
68 4,119,580 Method for forming agglomerated ion exchange resin
Metrohm的US专利
PAT. NO. Title
1 6,182,517 Burette tip
2 6,153,101 Device for ion-exchange chromatography and method of cyclically regenerating a plurality of suppressors of such a device
3 5,861,097 Method and device for preparing samples
4 5,686,829 Voltammetric method and apparatus
5 5,296,193 Combined titration apparatus
6 5,062,547 Volume measurement and dosage device
7 4,715,237 Process and apparatus for quantitative and/or qualitative analysis of liquids
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