德国应用化学

作为生命活动的执行者，蛋白质通过相互作用形成复合物等形式行使其特定的生物学功能。近日，中国科学院大连化学物理研究所研究员张丽华、研究员赵群等研制了一种基于糖苷键的质谱可碎裂型交联剂，显著地提高了交联信息的检索通量和鉴定准确度，同时具有良好的两亲性和生物兼容性，实现了活细胞内蛋白质复合物原位交联和规模化精准解析。相关成果发表在《德国应用化学》上。大连化物所供图　　细胞内的限域效应、拥挤效应和细胞器微环境等对于维持蛋白质复合物结构和功能至关重要。而化学交联技术，尤其是原位化学交联质谱技术具有规模化分析蛋白复合物原位构象和相互作用界面的优势，已成为活细胞内蛋白质复合物解析的重要技术。但是，目前活细胞原位交联面临着细胞扰动大、交联肽段谱图复杂程度高等问题。因此，如何实现活细胞低扰动下的原位快速交联是蛋白质原位构象和相互作用精准解析的先决条件。　　本工作中，团队基于糖分子的高生物兼容性和糖苷键的质谱可碎裂特征，将糖苷键引入到功能交联剂的骨架设计中，筛选并获得了高生物兼容性的海藻糖作为骨架分子，研制了质谱可碎裂型交联剂——海藻糖二琥珀酰亚胺酯。该交联剂较目前已报道的可透膜型化学交联剂，展示了更加优异的细胞活性维持能力，可在低扰动状态下实现细胞内蛋白质复合物的高效交联。　　在此基础上，低能量的糖苷键—高能量的肽键的质谱选择性碎裂模式，可以将“工字形”的交联肽段数据分析降幂为常规交联剂片段修饰的线性肽段数据检索，极大地降低了交联肽段谱图分析的复杂性，显著地提高了交联肽段的鉴定效率与准确度。

祝贺中国科技大学路军岭教授课题组：论文原位谱学表征和理论计算识别CO2加氢制甲醇催化剂中部分还原的ZnO1-x/Cu界面成功在《德国应用化学》(Angewandte Chemie)期刊发表。原文摘要：全球二氧化碳排放引发的温室效应令人担忧，先通过可再生能源得到绿氢，之后将二氧化碳加氢为能源小分子甲醇，被誉为“液态阳光”，是一个备受瞩目的技术可行方案。Cu/ZnO/Al2O3催化剂作为合成气制甲醇中成功应用了数十年的工业催化剂，在CO2加氢制甲醇中受到了广泛关注。然而，学术界对于Cu/ZnO/Al2O3催化剂活性位的鉴定，特别是Zn物种在反应状态下的结构和作用仍存在很大争议：研究集中于识别催化剂活性中心是CuZn合金形式存在的金属ZnO，还是Zn-O-Cu界面形式存在的氧化态Znδ+。近日，中国科学技术大学的路军岭教授及合作者精准构筑了含高分散ZnO物种的倒置型ZnO/Cu模型催化剂，他们通过精确构筑倒置型高分散ZnO/Cu模型催化剂，化学吸附测定的亲氧性物种与性能关联，高压原位XAFS谱学表征以及全面的理论计算和动力学模拟，证实了ZnO/Cu活性界面的化学本质与界面处的氧空位直接相关，在原子尺度上加深了对Cu-ZnO界面的认识，将CuZn体系活性位结构的识别向前推进了重要一步。以上研究成果再次验证了磐诺A91Plus气相色谱仪可满足科研工作者的学术研究，在精准定量目标物质的检测工作中，提供长时间可靠的分析数据。磐诺始终致力于成为中国乃至全球应用化学与生命科学市场的领跑者，能最大地帮助科研单位更快速、更准确地进行科学研究。本次发表的文章，也表现出磐诺气相色谱仪已具备针对顶级学术期刊的科研分析检测能力。再次恭喜路军岭教授团队能够取得佳绩，感谢一路走来对磐诺仪器的支持与认可！

p style=" text-indent: 2em " 6月6日，中国化学会官方网站发布郑重声明谴责于《德国应用化学》（Angewandte Chemie International Edition）6月4日在线发表（just accepted）文章的作者Tomas Hudlicky。该作者针对1990年发布的论文 strong span style=" background-color: rgb(255, 192, 0) " “Organic synthesis—Where now?” /span /strong 发表了评论性观点，观点中多处涉及性别歧视、种族歧视等不当言论， span style=" background-color: rgb(255, 255, 255) color: rgb(51, 51, 51) font-family: " microsoft=" " text-align:=" " 尤其作者对中国化学界的武断判断及诋毁，伤害到了致力于为化学学科发展不懈奋斗的中国化学家群体。 /span /p p style=" text-indent: 2em " span style=" background-color: rgb(255, 255, 255) color: rgb(0, 0, 0) " strong 该文章部分内容大意：“在 21 世纪，更多有机合成领域的出版物来自中国，而非任何其他国家。 span style=" background-color: rgb(255, 255, 255) color: rgb(192, 0, 0) " 中国学者在‘西方’期刊 /span 上发表文章的压力是巨大的， span style=" background-color: rgb(255, 255, 255) color: rgb(192, 0, 0) " 因此欺诈和不当的论文发表 /span 行文是常见的， span style=" background-color: rgb(255, 255, 255) color: rgb(192, 0, 0) " 这并不奇怪 /span 。” /strong /span /p p style=" text-indent: 2em " span style=" background-color: rgb(255, 255, 255) color: rgb(51, 51, 51) font-family: " microsoft=" " text-align:=" " /span /p p style=" text-align: center" img style=" max-width: 100% max-height: 100% width: 494px height: 295px " src=" https://img1.17img.cn/17img/images/202006/uepic/c3decab0-b312-4411-a1ee-2865be48c124.jpg" title=" 微信截图_20200608173312.png" alt=" 微信截图_20200608173312.png" width=" 494" height=" 295" / /p p style=" text-align: center" img style=" max-width:100% max-height:100% " src=" https://img1.17img.cn/17img/images/202006/uepic/90cd138d-96c4-458d-b29f-9962a9b9bb10.jpg" title=" 论文节选 图源网络.png" alt=" 论文节选 图源网络.png" / /p p style=" text-indent: 0em text-align: center " strong span style=" background-color: rgb(255, 255, 255) color: rgb(51, 51, 51) font-family: " microsoft=" " text-align:=" " 目前，该观点性文章迫于压力已经被撤回。 /span /strong /p p style=" text-align: center" img style=" max-width: 100% max-height: 100% width: 575px height: 592px " src=" https://img1.17img.cn/17img/images/202006/uepic/4e70eb99-9347-4447-8f8c-6225ee990c89.jpg" title=" 11111111111111111.png" alt=" 11111111111111111.png" width=" 575" height=" 592" / /p p br/ /p section data-tools=" 135编辑器" data-id=" 95122" style=" margin: 0px padding: 0px max-width: 100% color: rgb(51, 51, 51) font-family: -apple-system-font, BlinkMacSystemFont, " helvetica=" " pingfang=" " hiragino=" " sans=" " microsoft=" " yahei=" " letter-spacing:=" " text-align:=" " white-space:=" " background-color:=" " box-sizing:=" " border-box=" " overflow-wrap:=" " break-word=" " section data-width=" 100%" style=" margin: 10px auto padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important width: 677px " section style=" margin: 0px 0px -10px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important text-align: center transform: rotate(0deg) " section style=" margin: 0px padding: 3px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important display: inline-block background: rgb(255, 0, 0) " section data-brushtype=" text" style=" margin: 0px padding: 5px 1.5em max-width: 100% box-sizing: border-box word-wrap: break-word !important border-width: 1px border-style: solid border-color: rgb(170, 209, 198) letter-spacing: 1.5px color: rgb(255, 255, 255) " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 20px " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " 郑重声明 /strong /span /section /section /section section style=" margin: 0px 0px -14px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important display: flex justify-content: flex-end " section style=" margin: -14px 0px 0px padding: 0px max-width: 100% box-sizing: border-box width: 5px height: 5px border-bottom: 1px solid rgb(255, 0, 0) border-left: 1px solid rgb(255, 0, 0) background-image: initial background-position: initial background-size: initial background-repeat: initial background-attachment: initial background-origin: initial background-clip: initial border-right: none border-top: none overflow: hidden overflow-wrap: break-word !important " br style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " / /section /section section data-width=" 100%" style=" margin: 0px auto padding: 0px max-width: 100% box-sizing: border-box word-wrap: break-word !important width: 677px border-width: 1px border-style: solid border-color: rgb(255, 0, 0) " section style=" margin: 0px padding: 3px max-width: 100% box-sizing: border-box word-wrap: break-word !important " section style=" margin: 0px padding: 1em 0px 0px max-width: 100% box-sizing: border-box word-wrap: break-word !important border-width: 1px border-style: solid border-color: rgb(255, 0, 0) " section data-autoskip=" 1" style=" margin: 0px padding: 1em max-width: 100% box-sizing: border-box word-wrap: break-word !important font-size: 14px letter-spacing: 1.5px line-height: 1.75em " p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-indent: 0em line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 16px " 《德国应用化学》（Angewandte Chemie International Edition）杂志于6月4日在线发表（just accepted）作者Tomas Hudlicky的观点文章。文章中多处涉及性别歧视、种族歧视等不当言论，作为化学领域学术团体，中国化学会坚决反对作者观点。尤其是作者对中国化学界的武断判断及诋毁，是对致力于为化学学科发展不懈奋斗的中国化学家群体的整体伤害，已经迅速在中国化学领域引起了广泛的关注和愤慨。 /span /strong /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-indent: 0em line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " br style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " / /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-indent: 0em line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 16px " 中国化学会对作者Tomas Hudlicky予以强烈谴责，要求其尽快改正并公开道歉。希望《德国应用化学》调查该事件并以此为鉴，坚定科学多元化的立场，完善同行评议程序，秉持科学精神，确保此类事件不再发生。 /span /strong /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-align: right text-indent: 0em line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 16px " 中国化学会 /span /strong /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-align: right text-indent: 0em line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 16px " 2020年6月6日 /span /strong /p section data-tools=" 135编辑器" data-id=" 87580" style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " section style=" margin: 10px auto padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important text-align: center " section style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important display: inline-block " img data-ratio=" 0.029513888888888888" data-src=" https://mmbiz.qpic.cn/mmbiz/yqVAqoZvDibHW4ynpBjRrolMxOZtKTiaYgGib3Z1r7qO6vXvLcXPmzYxbdQeJ8vcQcICOj6WbeuYRM3kdvBzehtkA/640?wx_fmt=gif" data-type=" gif" data-w=" 1152" title=" 动态三角形分割线" _width=" auto" src=" http://mmbiz.qpic.cn/mmbiz/yqVAqoZvDibHW4ynpBjRrolMxOZtKTiaYgGib3Z1r7qO6vXvLcXPmzYxbdQeJ8vcQcICOj6WbeuYRM3kdvBzehtkA/640?wx_fmt=gif& tp=webp& wxfrom=5& wx_lazy=1" class=" __bg_gif" data-order=" 1" data-fail=" 0" style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important height: auto !important width: auto !important visibility: visible !important " / /section /section /section p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-align: center box-sizing: border-box !important overflow-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 18px font-family: arial, helvetica, sans-serif " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " Statement from Chinese Chemical Society /strong /span /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em box-sizing: border-box !important overflow-wrap: break-word !important " br style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " / /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-align: left line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-family: arial, helvetica, sans-serif " em style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important overflow-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 16px line-height: 24px " Angewandte Chemie International Edition /span /em span style=" margin: 0px padding: 0px max-width: 100% font-size: 16px line-height: 24px " span class=" Apple-converted-space" & nbsp /span published (Just Accepted) an opinion essay by Tomas Hudlicky on June 4, entitled as span class=" Apple-converted-space" & nbsp /span em style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important overflow-wrap: break-word !important " “Organic synthesis—Where now?” is thirty years old. A reflection on the current state of affairs /em .” It contains inappropriate remarks on racial and gender discrimination. As an academic organization in chemical sciences in China, Chinese Chemical Society is completely opposed to such discrimination, especially the author’s opinionated judgements and slanders to the whole chemistry community in China. The words have severely hurt the feelings of, and caused widespread attention and strong indignation from the Chinese chemists who are committed to advancing the chemical sciences. /span /span /strong /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-align: left line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " span style=" font-family: arial, helvetica, sans-serif margin: 0px padding: 0px max-width: 100% font-size: 16px line-height: 24px box-sizing: border-box !important overflow-wrap: break-word !important " br style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " / /span /strong /p p style=" margin-top: 0px margin-bottom: 0px padding: 0px max-width: 100% clear: both min-height: 1em text-align: left line-height: 2em box-sizing: border-box !important overflow-wrap: break-word !important " strong style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important " span style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important word-wrap: break-word !important font-size: 16px line-height: 24px font-family: arial, helvetica, sans-serif " Chinese Chemical Society, on behalf of the whole chemistry community in China, strongly condemns the author of this article and demands a formal apology. Also we hope span class=" Apple-converted-space" & nbsp /span em style=" margin: 0px padding: 0px max-width: 100% box-sizing: border-box !important overflow-wrap: break-word !important " Angewandte Chemie /em span class=" Apple-converted-space" & nbsp /span will stand for the values of fairness and justice, and diversity which are the foundations of scientific development, and take effective measures to improve the peer-review process and make sure this will not happen again. /span /strong /p /section /section /section /section section style=" margin: -5px 0px 0px padding: 0px max-width: 100% box-sizing: border-box width: 5px height: 5px border-top: 1px solid rgb(255, 0, 0) border-right: 1px solid rgb(255, 0, 0) background-image: initial background-position: initial background-size: initial background-repeat: initial background-attachment: initial background-origin: initial background-clip: initial border-left: none border-bottom: none overflow: hidden overflow-wrap: break-word !important " br/ /section /section /section p style=" text-align: justify text-indent: 2em " span style=" font-size: 16px " span style=" background-color: rgb(255, 255, 255) color: rgb(51, 51, 51) font-family: arial, 宋体, sans-serif text-indent: 28px " 德国应用化学 /span span style=" color: rgb(51, 51, 51) font-family: arial, 宋体, sans-serif text-indent: 28px background-color: rgb(255, 255, 255) " 是德国的化学类期刊，由Wiley公司出版，化学领域的世界顶级期刊，全称：Angewandte Chemie International Edition,分德语版和英语版。Angew.Chemie 上收录的文章以简讯类为主，简讯主要分布在有机化学、生命有机化学、材料学、高分子化学等领域，无机化学、物理化学涉及相对较少。SCI收录期刊，2018年的 /span /span a target=" _blank" href=" https://baike.baidu.com/item/%E5%BD%B1%E5%93%8D%E5%9B%A0%E5%AD%90/574727" data-lemmaid=" 574727" style=" color: rgb(19, 110, 194) text-decoration: underline font-family: arial, 宋体, sans-serif text-indent: 28px background-color: rgb(255, 255, 255) font-size: 16px " span style=" font-size: 16px " 影响因子 /span /a span style=" color: rgb(51, 51, 51) font-family: arial, 宋体, sans-serif text-indent: 28px background-color: rgb(255, 255, 255) font-size: 16px " 为12. /span span style=" background-color: rgb(255, 255, 255) color: rgb(51, 51, 51) font-family: arial, 宋体, sans-serif text-indent: 28px " 257。 /span /p p style=" text-indent: 28px text-align: justify " strong span style=" color: rgb(51, 51, 51) font-family: arial, 宋体, sans-serif background-color: rgb(255, 192, 0) " 期刊主编官方道歉，称期刊中不会有这篇观点性文章的位置 /span /strong /p p style=" text-align: center" img style=" max-width:100% max-height:100% " src=" https://img1.17img.cn/17img/images/202006/uepic/ce6f62d1-d718-479e-b735-9f8823b64013.jpg" title=" zuixinhuiying.png" alt=" zuixinhuiying.png" / /p p style=" text-indent: 28px text-align: justify " span style=" background-color: rgb(255, 192, 0) " strong 该期刊主编Dr. Neville Compton，已于当地时间5日，在官网回应并致歉。 /strong /span /p p style=" text-indent: 28px text-align: justify " strong 原文大意： /strong /p p style=" text-indent: 28px text-align: justify " 30年前在Angewandte Chemie上最初发表的对“有机合成-现在的状况？”的评论文章“对当前状况的反思”最近被发表为被接受的文章。本文中表达的观点并不反映我们（德国应用化学杂志）对公平，可信赖和社会意识的价值观。传播可信赖的知识不仅是我们的责任，而且还应反对歧视，不公正和不平等。尽管观点和思想的多样性可以刺激变革和辩论，但这篇文章在我们的期刊中没有位置。 /p p style=" text-indent: 2em text-align: justify " 针对此事件，我们将进行内部调查，并在下周分享我们正在执行的操作，以确保不会再次发生这种情况。 strong 我们深感抱歉 /strong ...... /p p style=" text-align: justify text-indent: 2em " 我们致力于做出改变。我们可以并且将会做得更好。 /p p style=" text-indent: 2em " Dr. Neville Compton, /p p style=" text-indent: 2em " Editor-in-Chief /p p style=" text-indent: 2em " Angewandte Chemie /p p style=" text-indent: 2em " br/ /p p style=" text-indent: 2em " a href=" https://www.instrument.com.cn/news/20200609/540780.shtml" target=" _blank" span style=" color: rgb(192, 0, 0) " strong 论文歧视事件发酵中： /strong 16名委员辞职抗议，英国皇家化学会RSC呼吁消除歧视（性别歧视、种族主义、LGBTQ+等） /span /a /p p style=" text-indent: 2em " strong /strong br/ /p