Jana 建立了一套分析细胞培养的流感病毒A疫苗产品中糖蛋白的N-多糖类型的方法[6]。该方法主要的检测手段就是对N-多糖酶切后的寡糖进行APTS荧光标记,然后利用毛细管凝胶电泳进行分离检测。APTS标记的例子还有很多,比如Marie-Eve用APTS标记的方法,分析了聚合度在2-6的甲壳素与壳聚糖的混合物[7]。对于APTS在衍生化过程中所出现的很多不可预知的结果,Bui等人做了系统的研究[8],分别比较了不同类型的单糖及低聚糖与APTS反应后的峰面积大小,研究发现不同类型的糖与APTS的反应活性不同,其中氨基糖的反应活性最弱。该篇文献对于APTS的正确应用提供了非常好的指导。
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