The paper: S.E. Winter, et al., "Gut inflammation provides a respiratory electron acceptor for Salmonella," Nature, 467:426-9, 2010.
Salmonella is able to out-compete resident gut microbes by deriving energy from the immune response that is supposed to combat the pathogen, according to a study published in September in Nature. Inflammation in a mouse gut generates a sulfur-based molecule called tetrathionate, which Salmonella uses during respiration for enhanced growth. 下载链接： http://www.instrument.com.cn/download/shtml/155536.shtml
2，纤毛如何“交谈”
2. How cilia talk !
The paper: Q. Hu, et al., "A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution," Science, 329:436-39, 2010.
Primary (nonmotile) cilia -- sensory organelles in eukaryotic cells that act as antennae -- rely on membrane proteins to send and receive extracellular signals. New findings, published in the July issue of Science, show how cilia retain those membrane proteins -- a barrier at the base of cilia made up of proteins called septins. )
Septins, originally identified as cell division mutants in yeast, localize at the base of the cilium where they maintain a barrier to control the localization of membrane proteins. The discovery solves the long-standing mystery of how signaling proteins are retained in the primary cilium.
One of the paper's corresponding authors, Elias Spiliotis, is this month's Scientist to Watch. You can read more about septins, and how they may also help protect yeast from the effects of aging, in our October cover story by Yves Barral. 下载链接： http://www.instrument.com.cn/download/shtml/155537.shtml
3，呼吸链第一种酶结构确定:
3. Complex I enzyme revealed
The paper: R.G. Efremov, et al., "The architecture of respiratory complex I," Nature, 465:441-5, 2010.
The long-awaited structure of a bacterial complex I enzyme -- first in line in the energy-producing respiratory chain -- reveals important mechanics of this ubiquitous protein. Specifically, the structure shows how the enzyme hustles electrons and protons across membranes.
The paper: E. Boilard, et al., "Platelets amplify inflammation in arthritis via collagen-dependent microparticle production," Science, 327:580-83, 2010.
Researchers identify platelet "microparticles" -- tiny vesicles that bud from the membranes of activated platelets -- in the fluid of inflamed joints, which rarely contain blood. Importantly, depleting the microparticles using an antibody seemed to cure arthritis in mice.
论文：Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
发表期刊及时间：《科学》，1 October 2010
5. Mechanotransduction proteins found
The paper: B. Coste, et al., "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels," Science, 330:55-60, 2010.
A new family of proteins, characterized in a mouse cell line, shines new light on the previously mysterious molecular basis of mechanosensation in mammals. Called Piezos, these proteins have been identified as a critical molecular component in mechanically activated ion channels, which make possible several sensations, such as hearing, touch and pain. 下载链接： http://www.instrument.com.cn/download/shtml/155533.shtml
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