	Base material silica
	NUCLEOCEL ALPHA: chiral selector amylose tris-(3,5-dimethylphenylcarbamate) USP L51 Similar phases: Chiralpak® AD, Kromasil® AmyCoat™, Europak 01	Amylose
	NUCLEOCEL DELTA: chiral selector cellulose tris-(3,5-dimethylphenylcarbamate) USP L40 Similar phases: Chiralcel® OD, Kromasil® CelluCoat™, Eurocel® 01, Lux™ Cellulose-1	Cellulose

	NUCLEOSIL® CHIRAL-1 for enantiomer separation based on ligand exchange · USP L32 Base material NUCLEOSIL® silica, particle size 5 μm, pore size 120 Å, chiral selector L-hydroxyproline – Cu2+ complexes Principal interaction mode: formation of ternary mixed-ligand complexes with Cu(II) ions Differences in the stability of the diastereomeric complexes cause chromatographic separation. Eluent in column 0.5 mM copper sulfate solution Recommended application: enantiomers with two polar functional groups with the correct spacing such as α-amino acids, α-hydroxycarboxylic acids (e.g., lactic acid), N-alkyl-α-amino acids etc.
	NUCLEOSIL® CHIRAL-2 / NUCLEOSIL® CHIRAL-3 for enantiomer separation in organic eluent systems · USP L36 Base material NUCLEOSIL® silica, particle size 5 μm, pore size 100 Å, chiral selector for NUCLEOSIL® CHIRAL-2: N-(3,5-dinitrobenzoyl)-D-phenylglycine, for NUCLEOSIL® CHIRAL-3 the optical antipode of the CHIRAL-2 phase, "brush type" phases Principle interaction modes: charge-transfer interactions, hydrogen bonds, dipole-dipole interactions and steric effects Eluent in column n-heptane – 2-propanol – TFAA (100:0.05:0.05) Recommended application: analysis of stereoisomers such as separation of enantiomers and diastereomers, control of optical purity of plant protectives (pesticides, e.g., propionic acid derived herbicides), pharmaceuticals etc. and for product control in chiral organic syntheses
	For control of the optical purity of a substance, the two columns NUCLEOSIL® CHIRAL-2 and NUCLEOSIL® CHIRAL-3 allow to select conditions such that the minor enantiomer, which is present as an impurity, is eluted before the main peak. Thus, overlapping peaks are avoided. This makes an exact quantification of the impurity much easier.

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