闲鹤野云
第4楼2008/05/14
ICU患者脑膜炎败血黄杆菌的耐药性分析和研究
王冬国;王红戟;徐昌君
目的检测从ICU患者痰液标本中分离的产MBL、ESBL脑膜炎败血黄杆菌的耐药性状况,指导临床正确合理使用抗生素。方法用VITEK32鉴定菌株;双纸片协同试验筛选产MBL菌株、产ESBL菌株;药敏试验使用VITEK GNS143上机检测和K-B法检测加做的药敏试验。结果ICU患者痰液标本中的脑膜炎败血黄杆菌的产酶率为78.4%,其中产MBL为41.2%,产ESBL为29.4%,有4株同时产MBL和ESBL。美满霉素、万古霉素、力奈唑烷的耐药率分别为19.8%、1.98%、1.98%。结论脑膜炎败血黄杆菌在ICU患者的痰液标本中高耐药性的根本原因是高产酶率(高产MBL和ESBL)。万古霉素、力奈唑烷、美满霉素是治疗ICU患者呼吸道感染的最有效药物。
【作者单位】:台州市立医院;台州市路桥区疾病控制中心;台州市立医院 浙江台州318000;浙江台州318000
【关键词】:ICU患者;脑膜炎败血黄杆菌;MBL,ESBL;耐药率
【分类号】:R446.5
【DOI】:cnki:ISSN:1005-376X.0.2006-05-018
【正文快照】:
脑膜炎败血黄杆菌又称脑膜炎脓毒黄杆菌,属革兰阴性杆菌,是一种条件致病菌,当人体免疫力下降时常可引起各种感染,如新生儿脑膜炎、肺炎、败血症、心内膜炎,尤其在ICU引起院内感染[1]。脑膜炎败血黄杆菌既产金属β-内酰胺酶(metalloβ--lacta-mase,MBL),又产超广谱β-内酰胺酶(e
Analyzing and reserching of drug resistance about Chryseobacterium meningosepticum from ICU patients' specimen of sputum
WANG Dong-guo~1;WANG Hong-ji;XU Chang-jun(1.Taizhou Municipal Hospital;Taizhou 31800;China)
Objective To investigate drug resistance of Chryseobacterium meningosepticum which producing metallo-β-lactamase and extended-spectrum-β-lactamase from ICU patients' specimen of sputum so as to guide the rational application of antibiotics.Methods Identified the strains with VITEK 32;MBL was screened by double disk synergy and ESBL was screened by double disk synergy;Antimicrobial sensitivity of clinical isolated was tested by VITEK GNS143 and adding antimicrobial sensitivity was tested by Kirby-Bauer method.Results The rate of producing β-lactamase of Chryseobacterium meningosepticum was 78.4%,and the rate of producing MBL was 41.2%,the rate of producing ESBL was 29.4%,respectivily,four clinical isolates produced both MBL and ESBL.The resistance rate of Chryseobacterium meningosepticum clinical isolates to Minocycline,Vancomycin,Linezolid was 19.8%,1.98%,1.98%.Conclusions Why the high resistance rate of Chryseobacterium meningosepticum in ICU patients' specimen of sputum was that high producing β-lactamase(high producing MBL and ESBL).Vancomycin,Linezolid,Minocycline were the most effective agents for treatment in ICU patients' specimen of sputum.
【Keyword】:ICU patients;Chryseobacterium meningosepticum;MBL;ESBl;Resistance rate of sensitivity
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happymingxu
第6楼2008/05/14
Cataract syndrome of frog is associated with chryseobacterium meningosepticum,and the symptom is accites()、askew head()、cataract() etc.If the acute syndrome goes with some other diseases the death rate of frog is higher. Basis from many experimentations of sensitivity we filtrated the compounding of Wajunshaxin spray and Koufuwajunsahxing Powder and made a series of prevention and cure experimentations.
这是我拙劣的翻译,括号里面的没有翻译,请指教!!!
闲鹤野云
第8楼2008/05/14
这样改一下是否合适:
Cataract syndromes in frog associated with chryseobacterium meningosepticum included accites()、head tilt and cataract() etc.In acute cases or when secondary diseases developed, the death rates of frogs were much higher. Based on many sensitivity tests, we developed formula of Wajunshaxin spray and Koufuwajunsahxing Powder, which were tested through series of prevention and treatment experiments.
有一些你没有翻译出来。如关于季节和年龄的。具体的症状你也没翻译。你再翻译一下我给你修改。
何当奇
第10楼2008/05/14
蛙的白内障综合症是由脑膜炎败血黄杆菌感染而引起的一种传染性疾病,症状表现为腹水(腹部膨胀、肥大、严重腹水),歪头(脖子歪斜朝向一侧,身体失去平衡),白内障(眼角膜突出、发炎、炎症组织的白内障盖住眼睛晶体而造成失明)等。
The symptoms of frog cataract syndrome, one Infectious diseases caused by infection of flavobacterium meningosepticum, are ascites (abdominal distension, hypertrophy, serious ascites), torticollis ( slanted neck, balance loss), cataracte (corneal protrusion, inflammation, blindness caused by cover of the cataracte of the inflammation tissue on the lends) etc.