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Table of Contents
• Chapter One: Executive Summary
o Market Definitions
o Commercialization Challenges
o Development Trends
o Optical Biosensor Innovations
o Microminiaturization of Sensors
o Summary and Comparison of Results
• Chapter Two: Introduction
o Definitions and Categories
o Classification of Sensors Based on Analyte
o Classification by Measurement and Control
o Classification by Element and Operation
o Advantages of Biosensors
• Chapter Three: Biosensor Technology
o General Biosensor Technology
Liquid Handling Systems
Signal Processing and Data Analysis
Potentiostats
Software for Biosensor Data Analysis
Spectroscopic Transduction
Fourier Transform Infrared Spectroscopy
Spectrophotometers for Sensor Applications
Infrared Reflectance Probes
o High-Tech Biosensors
Miniaturization of Sensors
Nanoparticle Sensors
Quantum Dots
Representative Current High-Tech Biosensor Development Projects
Smart Sensors
o Biochemical Recognition
Enzyme Biocatalysts-Based Biosensors
Enzyme Inhibition
Bioaffinity-Based Biosensors
Immunosensors
Microorganism-Based Biosensors
Oxygen Demand and Inhibition
Genetically Engineered Microorganisms
o Signal Transduction
Potentiometric Transducers
Amperometric Transducers
Conductance Measurements
Optical Measurements
Fluorescence
Protein Chip System
Surface Plasmon Resonance
Electrochemical Surface Plasmon Resonance (E-SPR)
SPR Biosensor: Tool for Real-time Analysis of Biomolecular Interactions
Sensitive Optical Detection
o Sensors Based on the Piezoelectric Effect
Introduction
o Acoustic Transducers
Surface Phenomena of Piezoelectric Materials
o Sensor Manufacturing Technologies
Microfluidics and LOC Technologies
Microelectronic Manufacturing Technologies
Monolithic Semiconductor Technologies
Lithography
Ceramic-Based Sensors
Polycrystalline and Vitreous Systems
Thin- and Thick-film Technologies
Evaporation and Sputtering
Processing Polymer Films
Photolithography
Electrically Active Polymers
Fiberoptic Technologies
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• Chapter Four: Biosensor Applications
o Biomedical Applications
Special Requirements
Medical Imaging
Clinical Diagnosis
Chemical and Biosensors for Clinical in Vivo Monitoring
Point of Care Biosensor Applications
Advances in Point-of-Care Testing
Future POCT Innovations
The Future of POCT
Non-Clinical Diagnostics
Molecular Diagnostics Clinical Tests and Clusters
Nanoscale Devices and Nanotechnologies
Nanotubes for Biological Sensors
o Foodborne Microbial Pathogen Detection
E. Coli O157:H7
Liposome-Based Bacteria Sensors
New Food Sensor Techniques
New Detection Methods Improve Food Safety
Monitoring Food for Residues
Detection of Pathogens and Toxins in Food
Detection of Listeria Pathogen
Market Restraints on Food Diagnostics
o Environmental Pollution and Hazard Monitoring
Monitoring for Toxic Industrial Materials
Future Directions
o Biowarfare and Bioterrorism
Bioterrorism Gets Our Attention
Requirements For Sensing Biological Weapons
Technologies for Bioagent Detection
Biosensors for Chemical Agents
o Industrial Process Control
World Process Analytical Instrumentation Market
Market Penetration into Nonmedical Applications
• Chapter Five: The Biosensor Market
o Market Dynamics and Factors Effecting the Overall Segment
The Focus is on Development of Applications as well as Sensors
High Costs of Biosensor Development
Manufacturing and Product Problems
Biosensor Development Specialists Work Closely with Users
Technologies Synergistic with Biosensors are Maturing and Competing
Impact of Miniaturization and Nanotechnology
Rapid Development of Microarray Technology Encourages Investment
Need to Balance Fundamental Research and Application Development
Older Technologies are Difficult to Replace
Small Companies with Niche Markets verses Large Companies with Mass Markets
o Factors that are Expanding the Biosensor Market
Greater Expectations of Quality of Life
Innovative new Technologies and Applications
Collaboration among Industrial, Governmental, and Academic Laboratories
Growing Acceptance of Biosensor Methods
o Successful Biosensors
o Market Data
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• Chapter Six: Company Profiles
o Abbott Diabetes Care
o Abbott Laboratories
o ABTECH Scientific, Inc.
o Advanced Biosensor Inc.
o Affinity Sensors
o Affymetrix
o Agilent Technologies
o Akubio Ltd
o Alcove Surfaces GmbH
o Alnylam Pharmaceuticals
o Ambri Limited
o AMETEK Princeton Applied Research
o Antibodies Incorporated
o Applera Corporation
o Applied BioPhysics, Inc.
o Archemix Corp.
o BCR Diagnostics Inc.
o BD Biosciences
o Beckman Coulter
o Becton, Dickinson and Company
o Biacore International AB
o BioForce Nanosciences, Inc.
o Biophage Pharma, Inc.
o Biosite Incorporated
o Boston MicroSystems
o Bruker BioSciences Corporation
o Chemel AB
o Cholestech Corporation
o Ciphergen Biosystems
o CombiMatrix Corporation
o Cranfield University -- Institute of BioScience and Technology
o Cytoplex Biosciences
o Dade Behring Holding Inc.
o Diagnostic Products Corporation
o Diversa Corporation
o DuPont Microcircuit Materials
o Endress+Hauser, Inc.
o Ercon, Inc.
o Evident Technologies
o Farfield Sensors Ltd Unit 51
o FIAlab Instruments, Inc
o HTS Biosystems Incorporated
o Human Genome Sciences
o i-STAT Corporation,
o Ibis Technology Corporation
o Infineon Technologies AG
o Invitrogen Corporation
o Isis Pharmaceuticals, Inc.
o Johns Hopkins University
o Johnson & Johnson
o Luna Analytics
o Matsushita Electric Industrial Co., Ltd.
o MicroFluidic Systems, Inc.
o MicroTEC Gesellschaft f丒 Mikrotechnologie mbH
o Mitsubishi Electric Corporation
o Molecular Devices Corporation
o Molecular Probes, Inc.
o Nanotechnology Institute
o Neogen Corporation
o NeuroMetrix Inc.
o Nitrate Elimination Co., Inc. (NECi)
o Nomadics, Inc.
o Nova Biomedical
o PDSi Pinnacle
o Perkin Elmer
o Perlegen Sciences, Inc.
o PharmaNetics, Inc
o Prolinx, Inc.
o Qiagen
o QMED Inc.
o QTL Biosystems, LLC QTL Biosystems (UK) Ltd.
o Quantum Dot Corp.
o Rapid Biosensor Systems Ltd
o Reichert Analytical Instruments
o Roche Holding Ltd.
o Sensopath Technologies
o Sixth Sense
o Spacelabs Medical, Inc.
o Spectral Diagnostics Inc.
o SpectRx Inc.
o SRU Biosystems, Inc.
o Strategic Diagnostics Inc.
o Tetracore, Inc
o Thermo Electron Corporation
o Thermotron Industries
o Theron, Inc.
o ThreeFold Sensors
o Toshiba Medical Systems
o Transducer Technology, Inc.
o USAID Development Experience Clearinghouse
o XanTec bioanalytics GmbH
o Zyomyx, Inc.
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• Appendix A: Annotated List of Potentiostat
• Manufacturers and Distributors
• Appendix B: Ancillary Data Used to Support Market Assumptions
• Appendix C: Selected Recent U.S. Patents on Biosensors
o List of Exhibits
• Chapter one: Executive Summary
o Exhibit 1: Summary: World Market for Biosensors 2004-2009
• Chapter two: Introduction
o Exhibit 2: Summary of Common General Biosensor Applications
o Exhibit 3: General Classification of Technologies Used in the Design of Biosensors
o Exhibit 4: List of Specific Biosensor Applications
o Exhibit 5: Sensors Commonly Classified According to the Quantity That They Measure
o Exhibit 6: Important Applications of Biosensors
o Exhibit 7: General Types of Analyte-Bioreceptor Interactions
o Exhibit 8: Biochemical Recognition Molecules--Receptors
o Exhibit 9: Common Transducer Technologies Used in Biosensors Systems
• Chapter Three: Biosensor Technology
o Exhibit 10: Commercialization Challenges for General Biosensors
o Exhibit 11: Summary of Selected Commercial Flow Analyzers (Manufacturer, Price, Applications, Flow Diameter/Sample Throughput, Sample Injection/Number/Volume, Detectors, Accessories)
o Exhibit 12: Examples of Sensor Functions Facilitated by Microprocessor and Memory Built into a Smart Sensor
o Exhibit 13: Some Examples of Biomolecular Interactions Which Have Been Successfully Studied Using SPR
o Exhibit 14: Classical Materials and Processing Technologies Used to Fabricate Biosensors
o Exhibit 15: Advantages and Disadvantages of Silicon-Based Sensor Production (Monolithic Semiconductor Processing)
o Exhibit 16: Advantages of Applying Thin and Thick Films in Sensor Fabrication
o Exhibit 17: Advantages and Disadvantages of Applying Polymer Films in Sensors
o Exhibit 18: Some Advantages and Disadvantages of Fiberoptic
• Chapter Four: Biosensor Applications
o Exhibit 19: Number of Foodborne Disease Outbreaks and Cases by Etiology 2003 Summary Statistics
o Exhibit 20: Obstacles Common to All Commercially Viable Biosensors Used for Field Analytical Methods
o Exhibit 21: Important Factors in the Selection of Biosensors for Process Control Analyzers
• Chapter Five: The Biosensor Market
o Exhibit 22: World Biosensor Market by Geographical Region/Country (North America, European Union, Japan, China, Latin America, India, Eastern Europe, Rest of World) 2004-2009
o Exhibit 23: World Biosensor Market by General Application (Research Laboratories, Medical Applications, Industrial Control, Biodefense, Environmental) 2004-2009
o Exhibit 24: The World Market for Biosensors for Medical Measurement Applications by Application (Blood Glucose, Coagulation Rate, Cholesterol, Others) 2004-2009
o Exhibit 25: The World Market for Biosensors for Industrial Process Control by Type (Alcohol/Beverages/Fuel, Sugars/Carbohydrates, Dairy Products, Meat Products, Others) 2004-2009
• Appendix B: Ancillary Data Used to Support Market Assumptions
o Exhibit B-1: World Healthcare Expenditure (Government and Private) by Region, 2004-2009
o Exhibit B-2: World Markets for Bioanalytical Equipment by Type (Total Biohazard Diagnostics, Biochip Systems [LOC, Arrays], Protein Microarrays, and Total Analytical Microarrays), 2004-2009
o Exhibit B-3: Number of Biotech Companies by Region (North America, Europe, Asia/Pacific, Rest of World) 2004-2009