maxtall
第4楼2008/06/08
the file from upstair is great:
Correcting Peak Tailing Problems in Reversed Phase HPLC
Peak tailing in reversed phase HPLC continues to be a common complaint. It is particularly prevalent when
separating basic compounds and, therefore, a source of constant problems to those analyzing pharmaceutical
compounds by HPLC.
Peak tailing causes a number of problems, including lower resolution, reduced sensitivity, and poorer
precision and quantitation. Figure 1 illustrates how resolution between peaks and sample sensitivity is
negatively affected by peak tailing. Figure 2 illustrates how accuracy and precision of an analysis can suffer
because of the inability of data systems to identify exactly where a tailing peak begins and ends.