leotron
第4楼2006/09/05
关于µ-TAS大致可以如下定义:
A micro-total analysis system(µ-TAS), also known as a lab-on-a-chip, is a small (centimeter-sized) chip that contains micron-sized channels for fluid transport and other design elements, such as pumps, valves, and reactors that miniaturize, integrate, and automate complex, multistep chemical and biological processes
leotron
第5楼2006/09/05
上传四篇µ-TAS概念的提出者(1989年)德国Manz教授在不同时期的综述文章.
2002:Micro total analysis systems. 1. Introduction, theory, and technology 被引用600次
Micro total analysis systems. 2. Analytical standard operations and applications 被引用530次
2004:Micro total analysis systems. Recent developments 被引用214次
2006:Micro total analysis systems. Latest advancements and trends
leotron
第6楼2006/09/05
Andreas Manz教授介绍:
Prof. Dr. Andreas Manz
phone: +49 (0)231 1392-103 /-102
fax: +49 (0)231 1392-300
e-mail: manz (at) isas.de
Research Areas: Miniaturisation, Proteomics, Metabolomics
Professor Manz is one of the pioneers in microchip technology used for chemical applications. He was involved in the development of high speed analysers based on capillary electrophoresis, liquid chromatography and flow injection analysis. These analysers profit from the microfabrication know-how originally developed for microelectronics, from the small volumes obtainable, and from the high degree of integration. He did most of his previous research with his group at Ciba-Geigy Ltd. in Basel, Switzerland and at Imperial College in London, U.K.
He developed a novel concept for Miniaturized Total Analysis Systems (µ-TAS): sampling, any sample pretreatment, separation, and detection steps are all performed in an integrated microsystem. A chemical parameter, for example the concentration of a compound, is periodically transformed into an electronic or an optical signal. In fact, it is a hybrid combining the advantages of a sophisticated analysis system with the size of a chemical sensor.
The Manz Lab focuses on novel applications of chip technology in analytical chemistry and the life sciences:
1.Understanding of information flow in chemical and biochemical micro-environments: chips for metabolism and status of individual biological cells, for cell sorting, for small volume DNA amplification, and for investigations related to molecular biophysics.
2.Chemistry in picoliter to attoliter volumes: chips for manipulation of small volumes of sample, for multiplexing, for chemical microreactors, for enhanced detection limits and for investigating novel phenomena in very small channels.
3.Integrated micro analysers using external flow and sensing control: solving the on-line monitoring problems in environmental, process control and medical applications.
4.Separation techniques offering unlimited separation efficiency or extremely short analysis time: chips for electrophoresis and chromatography, especially in a cyclic set-up or operated in repetitive mode.
5.Hyphenated separation techniques offering large peak capacities: chips for hyphenation of sample preparation, separation and mass spectrometry, of chromatography and electrophoresis, isoelectric focusing or isotachophoresis.
更多信息请访问:ISAS (Institute for analytical sciences)