书名：Mass Spectrometry in Medicinal Chemistry 作者：Klaus T. Wanner and Georg Hofner 出版社：WILEY-VCH Verlag GmbH 时间：2007 目录：1 Mass Spectrometry in Bioanalysis – Methods, Principles and Instrumentation 2 Drug Screening Using Gel Permeation Chromatography Spin Columns Coupled with ESI-MS 3 ALIS: An Affinity Selection–Mass Spectrometry System for the Discovery and Characterization of Protein–Ligand Interactions 4 Library Screening Using Ultrafiltration and Mass Spectrometry 5 Continuous-flow Systems for Ligand Binding and Enzyme Inhibition Assays Based on Mass Spectrometry 6 Frontal Affinity Chromatography – Mass Spectrometry for Ligand Discovery and Characterization 7 MS Binding Assays – An Alternative to Radioligand Binding 8 Laser Desorption Assays – MALDI-MS, DIOS-MS, and SAMDI-MS 9 Tethering: Fragment-based Drug Discovery by Mass Spectrometry 10 Interrogation of Noncovalent Complexes by ESI-MS: A Powerful Platform for High Throughput Drug Discovery 11 Quantification of Protein–Ligand Interactions in Solution by Hydrogen/Deuterium Exchange (PLIMSTEX) 12 Protein-targeting Drug Discovery Guided by Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS) 13 Mass Spectrometry in Early Pharmacokinetic Investigations Mass Spectrometry in Medicinal Chemistry
Mass Spectrometry in Medicinal Chemistry
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