【求助】戊菌唑JMPR毒性评价英文报告中一段翻译请教

qxm798

2008/09/19

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专业英语

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Penconazole administered orally to mice and rats was rapidly
absorbed and excreted, predominantly in the urine. Female rats
eliminated more in the urine and less in the faeces than male rats.
Very low residues were found in organs and tissues in both males and
females.

Numerous metabolites were identified in urine and faeces. The
major metabolic pathways involved oxidation of the pentyl side chain
to alcohols and acids with sequential cleavage of the terminal
carbon. As the oxidation products were conjugated, the resulting
metabolic patterns were complex. More polar and conjugated products
were found in female rats. Cleavage of the alkyl bridge between the
two rings led to the formation of 1,2,4-triazole, which was a major
metabolic route in male rats.

自我翻译如下

戊菌唑经口喂向小鼠和大鼠可被迅速吸收和排泄，主要是在尿液中。雌性大鼠更多的通过尿液排除，在粪便中比雄性大鼠排除的要少。在雌性和雄性的器官和组织的残留物非常低。在尿液和粪便可以确定众多的代谢产物。主要代谢途径为参与氧化的戊侧链，以醇类和酸序列卵裂终端的碳。由于氧化产物共轭，由此产生的代谢模式复杂。在雌性大鼠中发现更多的极性和共轭产品。两个环之间的烷基桥断裂，导致形成1,2,4 -三唑，这是雄性大鼠体内戊菌唑的一个重大的代谢路线。

happyjyl 2008/09/19

More polar and conjugated products were found in female rats. 雌性大鼠体内的极性和共轭产物更多。 Cleavage of the alkyl bridge between the two rings led to the formation of 1,2,4-triazole, which was a major metabolic route in male rats. 在雄性大鼠体内，两个环之间的烷基裂解，生成1,2,4-3唑。这是戊菌唑在雄性大鼠体内的主要代谢途径。这里的major应该翻译成“主要的”。alkyl bridge实际就是指连接两个环的烷基，这里的bridge可以不译。

何当奇 2008/09/19

[quote]原文由 [B]happyjyl[/B] 发表: 小鼠和大鼠口服给予戊菌唑后迅速吸收和排泄（主要由尿排泄）。与雄性大鼠相比，雌性大鼠通过尿液排出的量较多，通过粪便排出的量较少。雄性和雌性大鼠组织和器官中的戊菌唑残留量均非常低。 administered orally－药理学专业里对应的名词是“口服给药”。 [/quote] 农药毒理里面是经口给服，皮肤接触为经皮。其它的同

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happyjyl

第1楼2008/09/19

小鼠和大鼠口服给予戊菌唑后迅速吸收和排泄（主要由尿排泄）。与雄性大鼠相比，雌性大鼠通过尿液排出的量较多，通过粪便排出的量较少。雄性和雌性大鼠组织和器官中的戊菌唑残留量均非常低。

administered orally－药理学专业里对应的名词是“口服给药”。

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happyjyl

第2楼2008/09/19

The major metabolic pathways involved oxidation of the pentyl side chain to alcohols and acids with sequential cleavage of the terminal carbon.

主要代谢途径为：戊基支链末端的碳原子连续裂解而氧化为醇和酸。

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happyjyl

第3楼2008/09/19

More polar and conjugated products were found in female rats.
雌性大鼠体内的极性和共轭产物更多。

Cleavage of the alkyl bridge between the two rings led to the formation of 1,2,4-triazole, which was a major metabolic route in male rats.

在雄性大鼠体内，两个环之间的烷基裂解，生成1,2,4-3唑。这是戊菌唑在雄性大鼠体内的主要代谢途径。

这里的major应该翻译成“主要的”。alkyl bridge实际就是指连接两个环的烷基，这里的bridge可以不译。

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何当奇

第4楼2008/09/19

农药毒理里面是经口给服，皮肤接触为经皮。
其它的同
happyjyl 发表:小鼠和大鼠口服给予戊菌唑后迅速吸收和排泄（主要由尿排泄）。与雄性大鼠相比，雌性大鼠通过尿液排出的量较多，通过粪便排出的量较少。雄性和雌性大鼠组织和器官中的戊菌唑残留量均非常低。

administered orally－药理学专业里对应的名词是“口服给药”。